A distinct subtype of M4/M5 acute myeloblastic leukemia (AML) associated with t(8:16)(p11:p13), in a patient with the variant t(8:19)(p11:q13)—Case report and review of the literature

Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogénétique hématologique

“…8 The second one was a young female patient with AML-M4 and a simple t (8;19). 29 The gene in 19q13 is unknown. Neither inv(8)(p11q13) involving TIF2/NCOA2 (nuclear receptor coactivator 2), described in seven cases, 11,12,[30][31][32][33] Fwere found in our series.…”

t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12

“…This 8p11-12 myeloproliferative disorder is phenotypically distinct from acute monoblastic and myelomonocytic leukemia with t(8;16)(p11;p13) (Bernstein et al, 1987;Heim et al, 1987;LaõÈ et al, 1987;Mitelman and Heim, 1992;Stark et al, 1995;Rodrigues Pereira Velloso et al, 1996;Sainati et al, 1996), and with t(8;22)(p11;q13) (LaõÈ et al, 1992), respectively. In addition, the breakpoints of t(8;16) and t(8;22) are dierent from each other, and are both localized centromeric to the breakpoint involved in MPD.…”

“…The short arm of chromosome 8, region p11-12, is involved in reciprocal translocations in acute myeloid leukemia (AML), subtype M5, and myelomonocytic leukemias with t(8;14) (p11;q11.1) (Slovak et al, 1991), t(8;22)(p11;q13) (LaõÈ et al, 1992), and t(8;16)(p11;p13) (Bernstein et al, 1987;Heim et al, 1987;LaõÈ et al, 1987;Mitelman and Heim, 1992;Stark et al, 1995;Rodrigues Pereira Velloso et al, 1996;Sainati et al, 1996), respectively. In the latter, the 8p11 gene involved, MOZ (monocytic leukemia zinc ®nger protein), has been identi®ed recently (Borrow et al, 1996).…”

ERF: Genomic organization, chromosomal localization and promoter analysis of the human and mouse genes

“…Both the human chromosome 19 and the mouse chromosome 7 have been associated with a number of abnormal phenotypes. Speci®cally, human chromosome 19 has been associated with a number of hematopoietic malignancies that involve translocations or trisomies (Johanson et al, 1994;Stark et al, 1995). Although the most common translocation, t(14;19)(q32;q13), involves the BCL3 gene (Tanaka et al, 1990;Yabumoto et al, 1994;Ohno et al, 1993), a number of case reports referring to abnormalities in chromosome 19q13 have been published (Paietta et al, 1988;Belge et al, 1992;Bartnitzke et al, 1989).…”