A Disulfide-Linked Naphthalimide Dimer for Hg(II) Detection in Aqueous Solution

Abstract

A disulfide linked naphthalimide dimer probe was designed for mercury ion (Hg(2+)) recognition in this work. The recognition was based on the strong affinity of mercury for sulfur. The experimental results revealed that the probe exhibited high selectivity and sensitivity toward Hg(2+) in comparison to other metal ions via a turn-on and reversible response to Hg(2+) in neutral buffer solution. More importantly, the probe demonstrated a linear response for Hg(2+) over a concentration range from 0 to 150 μM with a detection limit of 0.38 μM, which is just the limit of the safe concentration for humans. Upon addition of 150 μM Hg(2+), the enhancement of fluorescence reached a maximum (∼7-fold). The performances of the probe indicated that it could meet the selectivity requirements for biomedical and environmental application and also was sensitive enough to detect Hg(2+) in environmental and biological samples.

Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications

“…Zhang et al introduced a disulfide-linked naphthalimide dimer, 9, for detecting the Hg 2+ ion. 73 Compound 9 (Figure 7) shows a 7-fold enhancement in fluorescence intensity at 468 nm in the presence of Hg 2+ ions in Tris-HCl solution (5 mM, pH 7.4) containing 50% (v/v) EtOH because the two sulfur atoms of the disulfide bond in 9 provide high affinity toward Hg 2+ ions. The fluorescence enhancement of 9 was proportional to the concentration of Hg 2+ in the range of 0−150 μM, with a detection limit of 0.38 μM.…”

An l-cystine/l-cysteine impregnated nanofiltration membrane with the superior performance of an anchoring heavy metal in wastewater

“…As a family of so Lewis bases, sulfur-containing species own a highly polarizable donor center, enabling it to strongly coordinate with low-lying orbitals of so Lewis acids such as heavy metal ions according to Pearson's theory of Hard/So Acids and Bases (HSAB). [28][29][30][31][32][33][34][35] In this context, numerous organic sulfur compounds including thiols, thioethers, disuldes, and mercaptans have been adopted to prepare new materials with high removal efficiency of heavy metal ions such as Hg(II), Ag(I), Pb(II), and Cd(II). 36,37 For example, some thiol/thiofunctionalized covalent organic frameworks (COFs), metalorganic frameworks (MOFs), carbon nanotubes, mesoporous silicas, zeolites as well as porous carbons have been developed [38][39][40][41][42][43][44][45][46] and exhibit high efficiency, selectivity, and easy recyclable adsorption capability towards toxic heavy metal ions.…”

Highly selective colorimetric and fluorescent detection for Hg2+ in aqueous solutions using a dipeptide-based chemosensor

“…In recent years, fluorescent chemosensors for HTM based on amino acids or peptides have received many attentions because they dissolved well in aqueous solutions and exhibited selective and sensitive fluorescent responses to specific metal ions. [21][22][23][24][25][26][27][28][29][30][31][32] On the other hand, it is very rare to developing colorimetric chemosensors based on peptides for monitoring HTM. In the present study, we synthesized a new colorimetric chemosensor based on a dipeptide containing a disulfide bond as following reasons.…”