A diurnal rhythm in plasma renin activity in man.

Gordon, Richard D.; Wolfe, Lawrence K.; Island, Donald P.; Liddle, Grant W.

doi:10.1172/jci105464

Cited by 284 publications

(97 citation statements)

References 14 publications

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“…The rhythmicity of glucocorticoid secretion also disappears in this disorder. However , this coincidence may not imply that the circadian variation of PRA is dependent upon changes in adrenocortical function , since a normal circadian rhythm in renin secretion has been reported in subjects to whom nuneralocorticoid and glucocorticoid were continuously given at 4-hr intervals (Gordon et al 1966). It is consistent with the previous report (Kem et al 1973) that the present patients with primary aldosteronism showed low PRA values and the lack of its normal circadian rhythm throughout a day .…”

Section: Hyperthyroidismsupporting

confidence: 91%

“…6 correlates the PRA values at 8:00 a.m. with the median PRA levels the changes in PRA is quite similar to those previously observed in normal subjects during continuous recumbency while they received constant diets in equal portions at regular intervals throughout a day (Gordon et al 1966;Michelakis and Horton 1970). The present subjects were allowed to take an upright or sitting position for 10-20 min after blood-sampling as well as when they took regular diets and went to voluntary voiding, nevertheless every normal volunteer showed a similar variation of PRA at each time of a day.…”

Section: Hyperthyroidismsupporting

confidence: 83%

“…The renin-angiotensin (RA) system may also play a significant role in the control of water balance by its interaction with antidiuretic hormone (Malvin 1971). Recent studies have indicated that plasma renin activity (PRA) in normal subjects exhibits a marked circadian rhythmicity with the maxi mum in the forenoon and the minimum in the late afternoon (Gordon et al 1966; Michelakis and Horton 1970). However, little is known about the circadian variation of PRA in various diseases with abnormal RA-system or water-electrolyte metabolism.…”

mentioning

confidence: 99%

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Circadian Variations of Plasma Renin Activity and Plasma Osmolality in Various Physiological and Pathological States

Minai

1974

Tohoku J. Exp. Med.

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Section: Hyperthyroidismsupporting

confidence: 91%

Section: Hyperthyroidismsupporting

confidence: 83%

mentioning

confidence: 99%

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Circadian Variations of Plasma Renin Activity and Plasma Osmolality in Various Physiological and Pathological States

Minai

1974

Tohoku J. Exp. Med.

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“…The diurnal variations in plasma renin activity, 19 angiotensin II, 20 and the pressor response to angiotensin II infusion 21 have been reported in humans. We demonstrated, for the first time, circadian variations in the expression of the RAS components and observed marked differences in these variations between SHR and WKY hearts.…”

Section: Discussionmentioning

confidence: 97%

Augmented Diurnal Variations of the Cardiac Renin-Angiotensin System in Hypertensive Rats

et al. 2002

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Abstract-There are several controversies concerning the enhanced gene expression of cardiac renin-angiotensin system components in spontaneously hypertensive rats (SHR) compared with their normotensive control Wistar-Kyoto (WKY) rats. We hypothesized that these discrepancies arise from circadian fluctuations in gene expression. We examined the circadian mRNA expression of renin, angiotensinogen, ACE, and angiotensin type 1a (AT1a) and type 2 (AT2) receptors in the hearts of SHR and WKY rats by real-time quantitative reverse transcription-polymerase chain reaction. The cardiac mRNA expression of the renin-angiotensin system components showed circadian oscillations in both SHR and WKY rats. The amplitudes of these circadian fluctuations were greater in the SHR than in the WKY rats. The mRNA levels of the renin-angiotensin system components were also increased in the SHR compared with the WKY rats at many time points (especially during the dark phase). However, the levels of ACE, AT1a receptor, and AT2 receptor mRNA in the SHR and WKY rats were almost the same during the late light phase. In contrast to mRNA expression, ACE activity was similar both at the time of maximum and minimum mRNA expression. The AT1 receptor antagonist candesartan upregulated AT1a receptor mRNA and downregulated ACE mRNA at specific time points only in the SHR group. Our findings of differential diurnal expression of cardiac renin-angiotensin system genes in SHR and WKY rats appear to explain the discrepancies between prior studies. However, the physiological relevance of the differential circadian mRNA expression of the renin-angiotensin system components remains to be elucidated. Key Words: circadian rhythm Ⅲ renin-angiotensin system Ⅲ renin Ⅲ angiotensinogen Ⅲ angiotensin-converting enzyme Ⅲ receptors, angiotensin II Ⅲ rats, spontaneously hypertensive M any studies in the last 3 decades have found that the cardiac renin-angiotensin system (RAS) is independently regulated from the systemic RAS and plays important pathophysiologic roles in cardiac hypertrophy and remodeling. 1-3 Many studies have examined the differences in the cardiac RAS in spontaneously hypertensive rats (SHR) and their normotensive counterpart, the Wistar-Kyoto (WKY) rat; these studies have shown some discrepancies in the expression of RAS component genes in SHR and WKY rats 4 -8 (Table 1). Some data have indicated an increased mRNA expression of angiotensinogen, ACE, and angiotensin type 1a (AT1a) receptors in SHR compared with WKY rats, whereas other studies have found no differences between the two strains.Many physiological processes are under the control of a biologic clock. In mammals, the central circadian pacemaker is located in the suprachiasmatic nucleus of the brain, whose phase is directly light-entrained by the retina. 9 Recent experiments have shown that peripheral tissues also have oscillatory systems that contain a transcriptional-translational feedback loop of clock genes. 9 -11 The heart also contains fully functional internal clocks, and several car...

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“…The plasma levels of several hormones show a pattern compatible with the physiological pattern of BP. [15][16][17] Nevertheless, when sympathoadrenergic influences are eliminated, the physiological circadian variation of peripheral vascular resistance is abolished. 18 Apparently, the sympathoadrenergic system plays a major role in producing the physiological circadian BP variation.…”

Section: Discussionmentioning

confidence: 99%

Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention

et al. 1999

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Salt and water retention, a cardinal feature of nephrotic syndrome, was suggested to be an important factor leading to reduced diurnal blood pressure (BP) variation in renoparenchymal disease. Twenty-four hour BP (SpaceLabs SL 90207), 24-h urine excretion of catecholamines, plasma renin activity and plasma aldosterone concentration were therefore determined in 10 nephrotic patients with normal serum creatinine levels (group A, serum creatinine 1.0 ± 0.2 mg/dl), in 10 nephrotic patients with increased serum creatinine levels (group B, serum creatinine 2.4 ± 0.9 mg/dl) and in 20 controls matched in respect of age and BP. To study the direct influence of fluid volume overload, diurnal BP variation was determined before and after volume depletion by ultrafiltration in 10 patients with end-stage renal failure. Diurnal BP variation was characterised by the difference of mean BP during daytime (10 pm to 8

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A diurnal rhythm in plasma renin activity in man.

Cited by 284 publications

References 14 publications

Circadian Variations of Plasma Renin Activity and Plasma Osmolality in Various Physiological and Pathological States

Circadian Variations of Plasma Renin Activity and Plasma Osmolality in Various Physiological and Pathological States

Augmented Diurnal Variations of the Cardiac Renin-Angiotensin System in Hypertensive Rats

Studies on diurnal blood pressure variation in kidney diseases associated with excessive salt and water retention

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