A DNA and mitochondria dual-targeted photosensitizer for two-photon-excited bioimaging and photodynamic therapy

Abstract

The biological substrates and organelle multi-targeted photosensitizers for ultra-efficient cancer treatment through photodynamic therapy (PDT) are highly desirable. Herein, a multiple pyridinium anchored photosensitizer containing the triphenylamine unit, TPA-2PI has...

Design of Sonosensitizers Integrated with Resveratrol Motif for Synergetic Sonodynamic Therapy and Nuclear Factor Kappa B Transcription Suppression of Breast Cancer

“…To quantitatively compare their potency to generate ROS under ultrasonic sound, 9,10-anthracenediyl-bis (methylene)dimalonic acid (ABDA) was selected as an indicator of 1 O 2 . 25 As shown in Figure 3D and S1, the sonosensitizers induced a pronounced decrease in ABDA absorption under ultrasonic treatment (0.8 W•cm −2 ) within 15 min. Interestingly, TR2 and TR3 were significantly superior to TR1 in generating 1 O 2 under ultrasonic sound (Figure 1E).…”

“…No ESR signal for oxidated BMPO was observed when these compounds were treated with ultrasonic sound, indicating no production of ·OH or O 2 – (Figure S2). To quantitatively compare their potency to generate ROS under ultrasonic sound, 9,10-anthracenediyl-bis (methylene)­dimalonic acid (ABDA) was selected as an indicator of 1 O 2 . As shown in Figure D and S1, the sonosensitizers induced a pronounced decrease in ABDA absorption under ultrasonic treatment (0.8 W·cm –2 ) within 15 min.…”

Progress and perspectives: fluorescent to long-lived emissive multifunctional probes for intracellular sensing and imaging

“…107 Among the different ROS, hydrogen peroxide (H 2 O 2 ) is a well-known ROS that plays an essential role in physiology, health, and aging in living beings. 108,109 In this view, Kim and co-workers reported a TPA probe, SHP-Mito, for the ratiometric detection of mitochondrial H 2 O 2 . 107 SHP-Mito consisted of a naphthalene derivative as a TP active moiety, boronate-based carbamate as a H 2 O 2 active site, which also acted as a leaving group upon reaction with H 2 O 2 , and triphenylphosphonium as the mitochondrial-targeting site (Fig.…”

Photocaged DNA-Binding Photosensitizer Enables Photocontrol of Nuclear Entry for Dual-Targeted Photodynamic Therapy

“…22 Zhou et al recently proposed a strategy involving cationic triphenylamine PSs, which they report to bind DNA and potentially target mitochondria. 25 However, in all cases, although effective cell death with high potency was observed, with even damage to DNA demonstrated in some cases (i.e., via gel electrophoresis 21 or immunofluorescence staining 7 ), these studies had inefficient targeting of the nucleus, required carriers to deliver the PSs to the nucleus, administrated two PSs separately, or included metal complexes in their design.…”

“…Given the vital role of the nucleus for cancer cell survival, DNA-targeted anticancer treatment (compared to enzyme-targeted anticancer therapies) is a promising strategy to increase therapeutic efficacy, ,, as multiple cancers can be targeted simultaneously, including those that have metastasized. , DNA-targeted dual PSs in particular have the advantage of being more effective relative to traditional PSs when treating multidrug-resistant cancers since the effective concentration of PS is higher (i.e., less PS pumped out via efflux pumps) so that therapeutic effects can be amplified . Despite DNA damage constituting the most critical inducer of apoptosis, ,, making it one of the primary targets for anticancer drugs, , the nucleus has been generally undertargeted for dual-targeted PDT.…”