A DNA–Au nanomachine activated by dual types of biomarkers for multi-site imaging and gene silencing

Abstract

A programmed DNA-Au nanomachine has been constructed to achieve in situ imaging of transmembrane glycoprotein MUC1 and cytoplasmic miRNA-21 and trigger gene silencing therapy. The results of MCF-7 cells-specific imaging...

DNA-functionalized gold nanoparticles: Modification, characterization, and biomedical applications

“…Afterward, the surface modification of AuNPs is usually based on the formation of Au–S bonds. DNA-modified AuNPs (DNA-AuNPs) are highly stable and have diverse functionalization options ( Zhou et al, 2022a ; Chen et al, 2022 ). Moreover, modified nanomaterials exhibit properties that differ from those of both the AuNPs and DNA from which they derive.…”

Dual-targets fluorescent nanoprobe for precise subtyping of lung cancer

“…Hence, nanoparticles based on Au–S bonds have been widely used for the detection of specific biomolecules. 12–15 However, Au–S bonds are susceptible to the influence of high concentrations of glutathione (GSH) in the biological environment, leading to premature detachment and fluorescence recovery, which can result in false-positive signals. In this regard, Tang's group developed a strategy involving Au–Se bonds as a replacement for Au–S bonds.…”