A DNA-flow cytometric analysis of trichilemmal carcinoma, proliferating trichilemmal cyst and trichilemmal cyst.

Reinauer, Stephen; Goerz, G; Ruzicka, Thomas; Susanto, FX. Haryanto; Humfeld, S; Reinauer, H.

doi:10.2340/0001555574361363

Cited by 21 publications

(2 citation statements)

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“…Early flow cytometric analysis of PPTs demonstrated that 2 of 5 cases (40%) showed DNA aneuploidy. 11 In contrast, none of the 6 pilar cysts tested in that study showed aneuploidy. 11 Previous studies have also implicated a possible role for TP53 in the pathogenesis of PPT.…”

Section: Introductionmentioning

confidence: 63%

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Proliferating Pilar Tumors Are Characterized by Recurrent 15q, 6q, and 6p22.2 Alterations

Fischer

Lindeman

Ligon

et al. 2022

The American Journal of Dermatopathology

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:Proliferating pilar tumors (PPTs) are rare neoplasms of external root sheath derivation, which most commonly occur on the scalp of elderly women. Although typically showing classic histologic features such as trichilemmal type keratinization, a lobular architecture and peripheral palisading, squamous cell carcinoma (SCC) remains a common diagnostic pitfall. Therefore, we sought to explore the molecular pathogenesis of PPTs and compare it with that of cutaneous squamous cell carcinoma (cSCC). Herein, we describe the use of a next-generation DNA sequencing platform to provide the most comprehensive molecular genetic analysis to date of a cohort of 5 PPTs and compare them to 5 head and neck cutaneous SCCs. Recurrent broad arm-level gains of 15q and concurrent single-copy losses of 6q and 6p22.2 were observed in 4 of 5 (80%) PPT cases. Other recurrent mutations or alterations of significance were not found in PPTs. Notably, these chromosomal changes were not identified in any of the 5 cutaneous SCCs, which instead showed recurrent alterations in the known SCC driver genes TP53, CDKN2A, and NOTCH1. Here, we show for the first time that PPTs are molecularly distinct from cutaneous SCC and provide evidence that recurrent alterations in chromosome 15 and chromosome 6 are central to the pathogenesis of PPTs.

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Section: Introductionmentioning

confidence: 63%

“…11 In contrast, none of the 6 pilar cysts tested in that study showed aneuploidy. 11 Previous studies have also implicated a possible role for TP53 in the pathogenesis of PPT. Martín-Sanz et al 12 reported that PPTs frequently demonstrate TP53 alterations, as confirmed by fluorescence in situ hybridization (FISH) studies.…”

Section: Introductionmentioning

confidence: 63%

Proliferating Pilar Tumors Are Characterized by Recurrent 15q, 6q, and 6p22.2 Alterations

Fischer

Lindeman

Ligon

et al. 2022

The American Journal of Dermatopathology

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Non–Gastrointestinal Tract Associations of Helicobacter pylori Infection

Leontiadis¹,

Sharma²,

Howden³

1999

Arch Intern Med

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Helicobacter pylori infection is linked to conditions of the upper gastrointestinal tract, including peptic ulcer and gastric adenocarcinoma. It has also been associated with a wide variety of non-gastrointestinal tract conditions. However, the evidence in support of H. pylori infection as a cause of the non-gastrointestinal tract conditions is not widely understood. We reviewed the medical literature for publications and abstracts dealing with putative non-gastrointestinal tract associations of H. pylori infection. We appraised the level of evidence and applied it to an established set of 9 criteria for determining causation. We found that many studies examining a possible causal relationship have been uncontrolled or inadequately controlled. Studies have often failed to control for socioeconomic status. Studies of treating H. pylori infection in patients with these disorders have been poorly designed and inappropriately controlled, and therefore add little to the evidence base. Attention should be focused on appropriate testing for and treatment of H. pylori infection in patients with conditions that are of proven association, notably peptic ulcer disease.

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Tricholemmal Cyst

Requena¹,

Sangüeza²

2017

Cutaneous Adnexal Neoplasms

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A DNA-flow cytometric analysis of trichilemmal carcinoma, proliferating trichilemmal cyst and trichilemmal cyst.

Cited by 21 publications

References 0 publications

Proliferating Pilar Tumors Are Characterized by Recurrent 15q, 6q, and 6p22.2 Alterations

Proliferating Pilar Tumors Are Characterized by Recurrent 15q, 6q, and 6p22.2 Alterations

Non–Gastrointestinal Tract Associations of Helicobacter pylori Infection

Tricholemmal Cyst

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