A DNA–gold nanoparticle hybrid hydrogel network prepared by enzymatic reaction

Eguchi, Yuka; Kato, Takeshi; Tanaka, Tsutomu; Maruyama, Tatsuo

doi:10.1039/c7cc02435e

Cited by 43 publications

(17 citation statements)

References 37 publications

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“…Recently, this approach has been adopted to crosslink deoxyribonucleic acid (DNA)-Au NP hydrogel. This created new potential applications of this composite material such as bioimaging, diagnostics, and therapeutics [65]. Other than using bare metal NPs, some studies have utilized the functionalized NPs for crosslinking reaction.…”

Section: Synthesis Methods Of Noble Metal Nps–hydrogels Compositesmentioning

confidence: 99%

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

2019

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Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. On the other hand, noble metal particles, particularly gold (Au) and silver (Ag) nanoparticles (NPs), can be incorporated into the hydrogel matrix to form NP–hydrogel composite scaffolds with enhanced physical and biological properties. This review aims to highlight the potential of these hybrid materials in tissue engineering applications. Additionally, the main approaches that have been used for the synthesis of NP–hydrogel composites and the possible limitations and challenges associated with the application of these materials are discussed.

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Section: Synthesis Methods Of Noble Metal Nps–hydrogels Compositesmentioning

confidence: 99%

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

2019

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“…This suggests that the DNA could facilitate the UCNP‐Au NPs to form a confined and compact network by the electrostatic attraction. [ 21,22 ] The hydrogels displayed a maximum water content as high as 96 w%. Rheometry results indicate that the DNA–UCNP‐Au hydrogel has low viscosity (Figure 2D), which makes it injectable by a syringe (Figure 2E and Figure S7, Supporting Information).…”

Section: Figurementioning

confidence: 99%

Injectable and NIR‐Responsive DNA–Inorganic Hybrid Hydrogels with Outstanding Photothermal Therapy

et al. 2020

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Surgical excision is one of the main treatments for malignant tumors. However, high risk of tumour recurrence is a major challenge. Near‐infrared (NIR)‐light‐induced tumor photothermal therapy has been studied, while its clinical applications are still restricted due to the limited therapeutic effects. To address this, here, a novel NIR‐light‐responsive and injectable DNA‐mediated upconversion and Au nanoparticle hybrid (DNA–UCNP‐Au) hydrogel is developed. Due to the confined and concentrated environment induced by the interaction between adjacent DNA strands and UCNP‐Au NPs, an ultrastrong photothermal effect is observed. A photothermal efficiency as high as 42.7% is realized in the hydrogel, which is superior to pristine inorganic particles. Upon direct peritumoral injection of the hydrogel and with the treatment of 808 nm laser irradiation, tumors are eradicated and no recurrence is observed. Meanwhile, there are no side effects on normal tissues due to the local treatment. Taking advantage of the high phototherapeutic effect, biocompatibility, and flexible operability in this system, a novel approach for malignant tumor therapy is demonstrated.

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“…The polyadenine sequence strongly adsorbed onto AuNPs with high loading capacity. This method produced DNA-AuNP conjugates with much higher concentrations of DNA and AuNPs compared to another method prepared by polymerase chain reaction (PCR) elongation [45]. Spacers are linear duplexes formed by two ssDNAs that each contains a sticky end that is complementary to the sticky ends of crosslinkers.…”

Section: Sequence Design Of Crosslinker and Spacer Strands For Dna Gementioning

confidence: 99%

Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits

et al. 2021

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Molecular self-assembly of DNA has been developed as an effective construction strategy for building complex materials. Among them, DNA hydrogels are known for their simple fabrication process and their tunable properties. In this study, we have engineered, built, and characterized a variety of pure DNA hydrogels using DNA tile-based crosslinkers and different sizes of linear DNA spacers, as well as DNA hydrogel/nanomaterial composites using DNA/nanomaterial conjugates with carbon nanotubes and gold nanoparticles as crosslinkers. We demonstrate the ability of this system to self-assemble into three-dimensional percolating networks when carbon nanotubes and gold nanoparticles are incorporated into the DNA hydrogel. These hydrogel composites showed interesting non-linear electrical properties. We also demonstrate the tuning of rheological properties of hydrogel-based composites using different types of crosslinkers and spacers. The viscoelasticity of DNA hydrogels is shown to dramatically increase by the use of a combination of interlocking DNA tiles and DNA/carbon nanotube crosslinkers. Finally, we present measurements and discuss electrically conductive nanomaterials for applications in nanoelectronics.

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A DNA–gold nanoparticle hybrid hydrogel network prepared by enzymatic reaction

Cited by 43 publications

References 37 publications

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

Injectable and NIR‐Responsive DNA–Inorganic Hybrid Hydrogels with Outstanding Photothermal Therapy

Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits

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