2017
DOI: 10.1039/c6cc08472a
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A DNA kinetics competition strategy of hybridization chain reaction for molecular information processing circuit construction

Abstract: Herein we propose a hybridization chain reaction based kinetics competition strategy able to recognize the combination/sequence of input signals. Further, a DNA priority encoder and a keypad lock were constructed. This strategy allowed us to develop a one-pot assay that can automatically and smartly respond to multiple inputs.

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Cited by 10 publications
(8 citation statements)
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“…Despite the significant advantages of resetting photonic molecular keypad locks (Figure ), a limitation of such systems, as well as the enzymatic (Figure ) and chemical systems (Figures and ) discussed before, is the difficulty of tuning them to recognize a wide range of inputs. A possible solution to this problem is using DNA‐based molecular keypad locks, in which the specific and reversible interaction between complementary oligonucleotides is used to obtain multi‐input recognition. Another advantage of using DNA to scaffold molecular security systems is that it can be readily attached to solid support, which provides a means to wash out the chemical inputs and make the systems reset .…”
Section: Molecular Logic Gate‐based User Authorization Systemsmentioning
confidence: 99%
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“…Despite the significant advantages of resetting photonic molecular keypad locks (Figure ), a limitation of such systems, as well as the enzymatic (Figure ) and chemical systems (Figures and ) discussed before, is the difficulty of tuning them to recognize a wide range of inputs. A possible solution to this problem is using DNA‐based molecular keypad locks, in which the specific and reversible interaction between complementary oligonucleotides is used to obtain multi‐input recognition. Another advantage of using DNA to scaffold molecular security systems is that it can be readily attached to solid support, which provides a means to wash out the chemical inputs and make the systems reset .…”
Section: Molecular Logic Gate‐based User Authorization Systemsmentioning
confidence: 99%
“…Although the various DNA‐based molecular keypad locks developed so far demonstrate well a few advantages of using such systems, for example, the ability to authorize longer passwords, as well as the ability to tune and reset them, they also indicate several limitations of this technology. The need to wash the system, following each step, slows down the authorization process and the attachment to solid support prevents these systems from operating at the molecular level.…”
Section: Molecular Logic Gate‐based User Authorization Systemsmentioning
confidence: 99%
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