A dog model to study ovary, ovarian ligament and visceral pain

Boscán, Pedro; Monnet, Eric; Mama, Khursheed R.; Twedt, David C.; Congdon, Jonathan; Eickhoff, Jens; Steffey, Eugene

doi:10.1111/j.1467-2995.2011.00611.x

Cited by 39 publications

(44 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hence, if a drug decreases the MAC, it should be tested for its analgesic effects in awake patients [54]. The dosage of lidocaine selected in this study was based on MAC studies in dogs under anaesthesia [25] and studies in conscious dogs [55].…”

Section: Discussionmentioning

confidence: 99%

Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs

et al. 2016

View full text Add to dashboard Cite

BackgroundCentral sensitization is a potential severe consequence of invasive surgical procedures. It results in postoperative and potentially chronic pain enhancement. It results in postoperative pain enhancement; clinically manifested as hyperalgesia and allodynia. N-methyl-D-aspartate (NMDA) receptor plays a crucial role in the mechanism of central sensitisation. Ketamine is most commonly used NMDA-antagonist in human and veterinary practice. However, the antinociceptive serum concentration of ketamine is not yet properly established in dogs. Six dogs were used in a crossover design, with one week washout period. Treatments consisted of: 1) 0.5 mg/kg ketamine followed by continuous rate infusion (CRI) of 30 μg/kg/min; 2) 0.5 mg/kg ketamine followed by CRI of 30 μg/kg/min and lidocaine (2 mg/kg followed by CRI of 100 μg/kg/min); and 3) 0.5 mg/kg ketamine followed by CRI of 50 μg/kg/min. The infusion was administered up to 120 min. Nociceptive thresholds and ketamine serum concentrations were measured before drug administration, and at 5, 10, 20, 40, 60, 90, 120, 140 and 160 min after the start of infusion.ResultsMaximum concentration recorded was 435.34 ± 26.18 ng/mL, 582.34 ± 227.46 ng/mL and 733.77 ± 133.6 ng/mL for K30, KL30 and K50, respectively. The concentration at 120 min was 250.87 ± 39.87, 221.73 ± 91.03 and 343.67 ± 63.21 ng/mL at 120 min in K30, KL30 and K50, respectively. All the three infusion regimes maintained serum concentrations above 200 ng/mL. The thresholds returned towards baseline values within 20 min, after cessation of infusion.ConclusionSerum concentration to produce mechanical antinociceptive effects in dogs is between 100 and 200 ng/mL. All the three infusion regimes in this study provided antinociceptive effects throughout the infusions. In this study, we found that the serum concentration of ketamine to produce mechanical antinociceptive effects in dogs is above 200 ng/mL. All three infusion regimes provided antinociceptive effects throughout the infusions without causing harmful effects. Further studies are recommended in a clinical setting.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs

et al. 2016

View full text Add to dashboard Cite

show abstract

“…(2008) for both DEX and ACP dogs. This is likely due to the effect of surgical stimulation on anaesthetic requirement (Boscan et al. 2011).…”

Section: Discussionmentioning

confidence: 99%

Alfaxalone for total intravenous anaesthesia in dogs undergoing ovariohysterectomy: a comparison of premedication with acepromazine or dexmedetomidine

Herbert

Bowlt

Ford-Fennah

et al. 2013

Veterinary Anaesthesia and Analgesia

View full text Add to dashboard Cite

“…Ovariectomy with laparoscopy has been described with 1‐, 2‐, and 3‐ports in dogs and cats, and a 3‐port technique that allows for triangulation has been previously described in lions . The 2‐port technique with percutaneous transfixation of the ovary appeared to provide the best compromise between surgery duration and pain after surgery . However, it required a transcutaneous suspension of the ovary, impossible for the salpingectomy procedure.…”

Section: Discussionmentioning

confidence: 99%

Single‐Incision Laparoscopic Sterilization of the Cheetah (Acinonyx jubatus)

et al. 2015

Self Cite

View full text Add to dashboard Cite

Objective: To describe laparoscopic ovariectomy and salpingectomy in the cheetah (Acinonyx jubatus) using single-incision laparoscopic surgery (SILS). Study Design: Prospective cohort. Animals: Female cheetahs (Acinonyx jubatus)(n¼ 21). Methods: Cheetahs were randomly divided to receive either ovariectomy (n ¼ 11) or salpingectomy (n ¼ 10). The use and complications of a SILS port was evaluated in all of cheetahs. Surgery duration and insufflation volumes of carbon dioxide (CO 2 ) were recorded and compared across procedures. Results: Laparoscopic ovariectomy and salpingectomy were performed without complications using a SILS port. The poorly-developed mesosalpinx and ovarian bursa facilitated access to the uterine tube for salpingectomy in the cheetah. The median surgery duration for ovariectomy was 24 minutes (interquartile range 3) and for salpingectomy was 19.5 minutes (interquartile range 3) (P ¼.005). The median volume of CO 2 used for ovariectomy was 11.25 L (interquartile range 3.08) and for salpingectomy was 4.90 L (interquartile range 2.52), (P ¼.001) Conclusions: Laparoscopic ovariectomy and salpingectomy can be performed in the cheetah using SILS without perioperative complications. Salpingectomy is faster than ovariectomy and requires less total CO 2 for insufflation.

show abstract

A dog model to study ovary, ovarian ligament and visceral pain

Cited by 39 publications

References 27 publications

Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs

Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs

Alfaxalone for total intravenous anaesthesia in dogs undergoing ovariohysterectomy: a comparison of premedication with acepromazine or dexmedetomidine

Single‐Incision Laparoscopic Sterilization of the Cheetah (Acinonyx jubatus)

Contact Info

Product

Resources

About