A domiciliary study of urinary circadian rhythms in rheumatoid patients with particular reference to the effects of the time of administration of corticosteroid drugs [proceedings]

Knapp,; Kowanko, I C; Mahoney, PG; Pownall, R; Swannell, A J

doi:10.1111/j.1365-2125.1978.tb04631.x

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Also bound to a 24-h circadian rhythm, synchronization of the SCN master clock with peripheral organ clocks relies on tightly regulated expression of GC coupled to GC receptors (GR) within the organs themselves 31 . More than 50 years have passed since the evening administration of GC was found to induce nocturia, studies of which focused on urine production rhythm but not bladder capacity 32 .…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice

et al. 2023

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Peripheral clocks function to regulate each organ and are synchronized though various molecular and behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show that glucocorticoids are a key cue for the bladder clock in vitro and in vivo. A pBmal1-dLuc human urothelial cell-line showed significant shifts in gene expression after cortisol treatment. In vivo, rhythmic bladder clock gene expression was unchanged by bilateral adrenalectomy but shifted 4 h forward by corticosterone administration at the inactive phase. Moreover, the bladder clock shifted 8–12 h in mice that underwent both bilateral adrenalectomy and corticosterone administration at the inactive phase. These mice showed decreases in the diurnal rhythm of volume voided per micturition, while maintaining diurnal activity rhythms. These results indicate that the diurnal rhythm of glucocorticoid signaling is a zeitgeber that overcomes other bladder clock entrainment factors and coordinates the diurnal rhythm of volume voided per micturition.

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Section: Introductionmentioning

confidence: 99%

Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice

et al. 2023

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show abstract

“…Also bound to a 24-hour circadian rhythm, synchronization of the SCN master clock with peripheral organ clocks relies on tightly regulated expression of GC coupled to GC receptors (GR) within the organs themselves 31 . More than 50 years have passed since the evening administration of GC was found to induce nocturia, studies of which focused on urine production rhythm but not bladder capacity 32 .…”

Section: Introductionmentioning

confidence: 99%

Coordination of bladder peripheral clock and diurnal micturition pattern by glucocorticoids

Chihara

Negoro

Kono³

et al. 2022

Preprint

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Peripheral clocks function to regulate each organ and are synchronized though various molecular and behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show that glucocorticoids are a key cue for the bladder clock in vitro and in vivo. A pBmal1-dLuc human urothelial cell-line showed significant shifts in gene expression after cortisol treatment. In vivo, rhythmic bladder clock gene expression was unchanged by bilateral adrenalectomy but shifted 4 hours forward by corticosterone administration at the inactive phase. Moreover, the bladder clock shifted 8–12 hours in mice that underwent both bilateral adrenalectomy and corticosterone administration at the inactive phase. These mice saw decreases in the diurnal rhythm of volume voided per micturition, while maintaining diurnal activity rhythms. These results indicate that the diurnal rhythm of glucocorticoid signaling is a zeitgeber that overcomes other bladder clock entrainment factors and coordinates the diurnal rhythm of volume voided per micturition.

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Supraventricular tachycardia associated with continuous furosemide infusion

1991

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A domiciliary study of urinary circadian rhythms in rheumatoid patients with particular reference to the effects of the time of administration of corticosteroid drugs [proceedings]

Cited by 3 publications

References 2 publications

Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice

Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice

Coordination of bladder peripheral clock and diurnal micturition pattern by glucocorticoids

Supraventricular tachycardia associated with continuous furosemide infusion

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