A domino Knoevenagel hetero-Diels–Alder reaction for the synthesis of polycyclic chromene derivatives and evaluation of their cytotoxicity

Organocatalysis in Synthesis: L-Proline as an Enantioselective Catalyst in the Synthesis of Pyrans and Thiopyrans

“…The addition of active methylene reagents to arylidenemalononitrile in the presence of homogeneous basic catalysts has been extensively used in the past for the synthesis of these compounds [7,8,9,10,11,12]. Interest in these reactions has recently been revived [13,14] with the aim of developing green laboratory reaction conditions [15,16], such as replacing homogeneous catalysis with heterogeneous ones [17,18,19,20], to synthesize enantiomerically pure pyrans for which diverse biological applications were noticed [21,22,23] and patented [24,25,26]. Many of these new approaches use multicomponent reactions and either an organocatalyst [27,28] or sometimes metal or nanoparticulated catalysts [29,30,31].…”

Crystal structure of 3-amino-1-(4-bromophenyl)-9-methoxy-1H-benzo[f]chromene-2-carbonitrile, C21H15BrN2O2

“…Multi-nuclear O-heterocyclic compounds like benzochromenes are of wide interest because they exhibit a diverse range of biological activities [2,3], hypolipidemic [4], antioxidant [5,6], anticancer [5,7] analgesic [8], antileishmanial [9,10], vascular-disrupting [11], estrogenic anticoagulant and antispasmolytic [12], blood platelet antiaggregating [13] …”

Synthesis and Computational Analysis of New Antioxidant and Antimicrobial Angular Chromenopyrimidines

“…In addition, chromene scaffolds became privileged skeletons because of their wide medicinal activities . Because enhanced medicinal activity might be produced via combining two or more biologically active segments, pyrimidine and chromene units might be appropriate candidates to build an elegant hydrid model .…”