A Domino Reaction of Pyridinium Salts: Efficient Synthesis of 4,5‐Disubstituted 1,2,3‐(NH)‐Triazoles

Abstract

A one-pot mild and metal-free procedure for efficient synthesis of 4,5-disubstituted 1,2,3-(NH)-triazoles has been developed through the sequentially reaction of pyridinium salts with aldehydes and sodium azide. In the presence of L-proline, a key intermediate, an olefinic pyridinium-salt, is in situ generated via coupling of pyridinium salts with aldehydes and cyclizes with azide ion to form a triazole ring.