A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration

Zhan, Chenchang; Lin, Guifang; Huang, Yong; Wang, Ziqian; Zeng, Fang; Wu, Shuizhu

doi:10.1016/j.biomaterials.2020.120573

Cited by 48 publications

(32 citation statements)

References 54 publications

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“…Abundant previous reports have showed that the inhibition of NLRP3 inflammasome may contribute to ameliorate of ALF 31 . And in our study, we found that the level of NLRP3 inflammasome was increased in ALF which was consistent with previous results.…”

Section: Discussionsupporting

confidence: 93%

HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F‐actin signalling pathway

Chen

Wang

Jiao

et al. 2021

J Cellular Molecular Medi

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Acute liver failure (ALF) is a rare and critical medical condition. This study was designed to investigate the protective effects and underlying mechanism of ACY1215 in ALF mice. Our findings suggested that ACY1215 treatment ameliorates the pathological hepatic damage of ALF and decreases the serum levels of ALT and AST. Furthermore, ACY1215 pretreatment increased the level of ATM, γ‐H2AX, Chk2, p53, p21, F‐actin and vinculin in ALF. Moreover, ACY1215 inhibited the level of NLRP3, ASC, caspase‐1, IL‐1β and IL‐18 in ALF. The ATM inhibitor KU55933 could decrease the level of ATM, γ‐H2AX, Chk2, p53, p21, F‐actin and vinculin in ALF with ACY1215 pretreatment. The F‐actin inhibitor cytochalasin B decreased the level of F‐actin and vinculin in ALF with ACY1215 pretreatment. However, cytochalasin B had no effect on protein levels of ATM, Chk2, p53 and p21 in ALF with ACY1215 pretreatment. Cytochalasin B could dramatically increase the level of NLRP3, ASC, caspase‐1, IL‐1β and IL‐18 in ALF with ACY1215 pretreatment. These results indicated that ACY1215 exhibited hepatoprotective properties, which was associated with the inhibition of NLRP3 inflammasome, and this effect of ACY1215 was connected with upregulation of the ATM/F‐actin mediated signalling pathways.

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Section: Discussionsupporting

confidence: 93%

HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F‐actin signalling pathway

Chen

Wang

Jiao

et al. 2021

J Cellular Molecular Medi

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“…Previous studies have demonstrated that Kupffer cells produce important cytokines that induce cell proliferation after hepatectomy [3]. For the present study, it was hypothesized that, instead of performing a liver parenchymal transection after portal vein ligation (PVL), injecting polarized proinflammatory CD86 + macrophages could trigger a full inflammatory response and accelerate liver regeneration through the release of proinflammatory cytokines.…”

Section: Injection Of Cd86 + Macrophages Instead Of Liver Partition For the Acceleration Of Liver Regeneration After Portal Vein Ligationmentioning

confidence: 96%

“…Jinwei Zhao 1 , Weiyi Zhao 2 , Hong Zhou 1 , Hongyue Xu 1 , Lu Yu 1 Partial hepatectomy (PH) remains the first-line curative treatment for liver malignancies; however, an extended hepatectomy is accompanied by higher risk of postoperative liver failure, which is the most common cause of mortality after this procedure. Whether a hepatic resection is performed generally depends on preoperative liver function and the volume of the further liver remnant (FLR) [1][2][3][4].…”

Section: Injection Of Cd86 + Macrophages Instead Of Liver Partition For the Acceleration Of Liver Regeneration After Portal Vein Ligationmentioning

confidence: 99%

Injection of CD86+ macrophages instead of liver partition accelerates liver regeneration after portal vein ligation in rats

Zhao

Zhou

et al. 2021

Arch Med Sci

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“…The iron chelator DSe was a yellow oil product, which was synthesized according to the procedure reported in the literature. 27…”

Section: Synthesis Of 3-(mentioning

confidence: 99%

A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy

Chen

Gui³

et al. 2022

Biomater. Sci.

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A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration

Cited by 48 publications

References 54 publications

HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F‐actin signalling pathway

HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F‐actin signalling pathway

Injection of CD86+ macrophages instead of liver partition accelerates liver regeneration after portal vein ligation in rats

A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy

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