“…Several studies report in vivo experiments using both mouse (Pace et al, 1996, Partington et al, 1984and Perrine et al, 1988, both primates and humans (Constantoulakis et al, 1989a, Lavelle et al, 1993, Constantoulakis et al, 1988, Fucharoen et al, 2013aand Kutlar et al, 2013) models demonstrating the expected clinical effects of this class of foetal haemoglobin inducers. The activity of sodium butyrate and sodium phenylbutyrate and analogues exhibiting similar mechanism of action have been evaluated in clinical trials (Dover et al, 1994, Sher et al, 1995, Collins et al, 1995, Perrine et al, 2011and Patthamalai et al, 2014 demonstrating induction of foetal haemoglobin in some patients with thalassaemia.…”