A dose–response evaluation of freeze‐dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single‐blinded, diet‐controlled crossover trial

Park, Eun‐Young; Edirisinghe, Indika; Wei, Hequn; Vijayakumar, Lakshmi; Banaszewski, Katarzyna; Cappozzo, Jack; Burton‐Freeman, Britt

doi:10.1002/mnfr.201500845

Cited by 73 publications

(95 citation statements)

References 33 publications

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Section: Discussioncontrasting

confidence: 99%

“…It is unclear why our results differ from the significant reductions in postprandial insulin (27,28), as well as triglycerides and oxidized LDL (26), found in the 2 previous postprandial strawberry studies. Dairy proteins and the timing of meal intake may diminish the effects of polyphenols (56,57); however, significant benefits have been achieved with the use of a milkbased beverage consumed with a test meal (26,28). Although the amount of strawberries required to optimize effects on clinical outcomes is unknown, our 40-g dose of freeze-dried powder was equivalent to w3 cups of fresh strawberries [13 g freeze-dried powder is equivalent to 1 cup fresh (C Christian California Strawberry Commission, personal communication, 2014)] and provided a substantial amount of polyphenols (Supplemental Table 2).…”

Section: Discussioncontrasting

confidence: 99%

“…Based on our exploratory analyses, characteristics of our study population such as age and sex also may have influenced responses. Moreover, compared with the 2 previous postprandial strawberry studies (26,28), our participants tended to be younger, did not have elevated total or LDL cholesterol, and were not insulin resistant. Thus, the potential benefits of strawberries may be FIGURE 3 Mean 6 SEM changes in TGs (A), glucose (B), and insulin (C) after consumption of the control and freeze-dried strawberry test meals.…”

Section: Discussionmentioning

confidence: 72%

“…Although the amount of strawberries required to optimize effects on clinical outcomes is unknown, our 40-g dose of freeze-dried powder was equivalent to w3 cups of fresh strawberries [13 g freeze-dried powder is equivalent to 1 cup fresh (C Christian California Strawberry Commission, personal communication, 2014)] and provided a substantial amount of polyphenols (Supplemental Table 2). A similar amount of total anthocyanins was provided in the postprandial study by Park et al (28), although the freeze-dried strawberry powder used by BurtonFreeman and colleagues (26,27) had a higher oxygen radical absorbance capacity value and a higher concentration of select polyphenolic compounds, including quercetin and pelargonidin-3-glucoside. These differences may account, in part, for the discrepancies between our results and those of Burton-Freeman et al (26).…”

Section: Discussionmentioning

confidence: 96%

“…A modest attenuation of the 6-h postprandial triglyceride, insulin, and oxidized LDL response was found in overweight hyperlipidemic adults when 10 g freeze-dried strawberry powder was incorporated into a meal with 30 g total fat (26,27). In a subsequent study, incorporating 40 g freeze-dried strawberry powder into a high-carbohydrate meal with 25 g total fat significantly reduced the 6-h insulin response in individuals with insulin resistance, but had no effect on postprandial glucose, triglycerides, or oxidized LDL (28). Effects on postprandial central blood pressure and arterial stiffness have yet to be tested, and additional research is needed to evaluate the potential of strawberries to mitigate the metabolic consequences of consuming a high-fat meal in different study populations.…”

Section: Introductionmentioning

confidence: 92%

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Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

Richter

Skulas‐Ray

Gaugler

et al. 2017

The American Journal of Clinical Nutrition

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Background: Postprandial dysmetabolism-an exaggerated spike in triglycerides, glucose, and insulin-increases cardiovascular disease risk by inducing oxidative stress, inflammation, and endothelial dysfunction. Polyphenol-rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of polyphenols, but there is little research on their postprandial effects. Objective: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (w1 lb. or 0.45 kg fresh strawberries) to a high-fat (50 g total fat) meal on postprandial vascular function, as well as triglyceride, glucose, and insulin responses. Design: Healthy, overweight or obese [mean 6 SEM body mass index (in kg/m 2 ): 31 6 0.5] adults (mean 6 SEM age: 28 6 2 y; 17 men and 13 women) consumed a control meal and a strawberry meal in a randomized crossover design. Testing sessions were separated by $1 wk for men and w1 mo for women to control for hormonal variations. Blood samples were obtained before the meal and 0.5, 1, 2, and 4 h after the meal. Central blood pressure and arterial stiffness indexes were measured at baseline and 2 and 4 h postmeal with the use of pulse waveform analysis. Results: There were no significant differences between the strawberry and control meals for any outcomes. Consumption of either meal significantly decreased the augmentation index at 2 and 4 h (P , 0.002) and significantly increased triglycerides, insulin, and glucose at all time points (P , 0.001) relative to baseline. Conclusions: The strawberry intervention did not alter vascular function or attenuate postprandial metabolic derangements in triglycerides, glucose, or insulin relative to the control meal. Additional research is needed to clarify whether strawberries or other polyphenol-rich interventions improve postprandial responses, and future studies should take into account the acute meal-induced improvements in measures of vascular function. This trial was registered at clinicaltrials.gov as NCT01989637.Am J Clin Nutr 2017;105:313-22.

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