A Double Blind Comparative Study of I.V. Clonidine and Fentanyl to See the Haemodynamic Response During Laryngoscopy and Intubation

Charan, Nameirakpam; Hijam, Bijaya; Ninave, Sanjot; S, Thoibahenba Singh; Keisham, Upendra; Heisnam, Ibemhal

doi:10.14260/jemds/2014/3300

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…These findings were similar to the findings found in the study done by Nameirakpam Charan et al 14 who found that Intravenous Clonidine was found to be more effective than intravenous Fentanyl in attenuating pressure response to laryngoscopy and intubation with the minimum equipotent dose. Anish Sharma N.G 15 and Shankaranarayana P P conclude that both clonidine and dexmedetomidine attenuates the pressor response during laryngoscopy and Intubation but Dexmedetomidine is better in attenuating the tachycardia response.…”

Section: Discussionsupporting

confidence: 91%

Intravenous low dose clonidine premedication for attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation

Kavi

Mallappa

et al. 2015

Int J Res Med Sci

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Section: Discussionsupporting

confidence: 91%

Intravenous low dose clonidine premedication for attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation

Kavi

Mallappa

et al. 2015

Int J Res Med Sci

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“…Our findings are consistent with those of Biswas BN et al [10] who identified a 5% incidence of nausea and vomiting in their research. Some of the related studies on different combinations in anaesthesia were reviewed [13][14][15][16][17][18]. Clonidine can cause nausea and vomiting, however these are uncommon side effects.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Intrathecal Bupivacaine with Clonidine Versus Intrathecal Bupivacaine with Fentanyl for Post-operative Pain Treatment in Lower Limb Procedures

Deshmukh

Parate

Agrawal

et al. 2021

JPRI

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Background: One of the anaesthesiologist's key goals during spinal anaesthesia is to keep the body physiology as close to normal as feasible. As we all know, subarachnoid block causes significant hemodynamic changes, especially in trauma and elderly individuals. Sympathetic nervous system denervation, skeletal muscle weakness, or loss of proprioception are not linked to neuraxial opioids. They primarily operate on the receptors found in the substantia gelatinosa of the spinal cord to exert their synergistic analgesic impact on visceral pain. Opioids and local anaesthetics delivered intrathecally have a powerful synergistic analgesic effect. A 2 adrenergic agonist, Clonidine is sometimes used as a local anaesthetic adjuvant with mixed effects. The effects of intrathecal Clonidine vs Fentanyl with 0.5 percent hyperbaric bupivacaine on postoperative analgesic duration and adverse effects were compared. Objectives: The purpose of this study was to compare the efficacy of 0.5 percent hyperbaric bupivacaine with Clonidine (75 gs) vs Fentanyl (25 gs) for spinal anaesthesia in patients undergoing lower limb procedures, as well as the postoperative pain alleviation and adverse effects in both groups. Methods: This was a prospective study involving 80 patients who were scheduled for elective lower limb surgery under spinal anaesthesia. The participants were randomly assigned to one of two groups: Group C (15mg 0.5 percent bupivacaine + 75gs Clonidine) or Group F (15mg 0.5 percent bupivacaine + 25gs Fentanyl). Results: We discovered a time delay in the start of sensory and motor block in group C after assessing the outcomes of our investigation. Group C's sensory and motor block lasted significantly longer compared to group F. The average duration of analgesia in groups C and F was 234.7529.71 minutes and 170.8732.38 minutes, respectively. Compared to group C, the demand for rescue analgesics was higher in group F throughout 24 hours. Bradycardia affected 12 individuals in group C, while pruritus affected 12 patients in group F. Five of the patients in group F experienced nausea. Conclusion: In compared to 25gs Fentanyl, adjuvant use of Clonidine 75gs with hyperbaric bupivacaine prolongs the duration of both sensory and motor blockage, as well as the length of analgesia postoperatively, without generating substantial hemodynamic compromise or other side effects.

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Efficacy of Oral Gabapentin for Attenuation of Haemodynamic Responses to Laryngoscopy & Endotracheal Intubation

Venigalla¹,

Ninave²

2021

jemds

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BACKGROUND Laryngoscopy and endotracheal intubation are basic skills to be acquired by an anaesthesiologist. For many years, laryngoscopy has been used as a conventional way to facilitate endotracheal intubation. These are the most critical events because, they provoke a marked rise in sympathoadrenal response as hypertension and tachycardia. There is an absolute need to decrease these haemodynamic responses, for which various drugs were used, with varying degrees of success. Gabapentin, initially used as an anticonvulsant has extended its role into anaesthesia practice with its multimodal effects. This study was conducted to evaluate the efficacy of oral gabapentin 800 mg in attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation. METHODS After obtaining institutional ethical clearance, a prospective randomised comparative study was undertaken. Written and informed consent was obtained from 80 patients belonging to American Society of Anaesthesiologists (ASA) class I & II scheduled for various elective surgeries under general anaesthesia. They were divided into two groups of 40 each using computer generated random number table. Group G received oral gabapentin 800 mg and group C received empty capsules with sips of water, 2 hours prior to induction. Haemodynamic parameters – heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) were noted and rate pressure product (RPP) was calculated at baseline, at laryngoscopy and then at 1, 3, 5, 10 & 15 minutes after laryngoscopy and endotracheal intubation. RESULTS In Group G there was significant attenuation of HR, SBP, DBP, MAP at 1, 3 and 5 minutes after laryngoscopy and endotracheal intubation as compared to Group C. Hence, in Group G there was significant attenuation of RPP at 1 minute (12673.60 ± 1691.25, 11769.08 ± 1146.02, P = 0.01), 3 minutes (12546.85 ± 1123.78, 11759.98 ± 1358.02, P = 0.01) and 5 minutes (12411.68 ± 1270.04, 11537.03 ± 1230.06, P = 0.002) after laryngoscopy and endotracheal intubation as compared to Group C. No statistical difference was seen at 10 and 15 minutes. CONCLUSIONS Oral gabapentin 800 mg given preoperatively can attenuate haemodynamic responses to laryngoscopy and endotracheal intubation without significant side effects. KEY WORDS Oral Gabapentin, Laryngoscopy, Endotracheal Intubation, Haemodynamic Changes, Attenuation, Pressor Responses

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A Double Blind Comparative Study of I.V. Clonidine and Fentanyl to See the Haemodynamic Response During Laryngoscopy and Intubation

Cited by 4 publications

References 11 publications

Intravenous low dose clonidine premedication for attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation

Intravenous low dose clonidine premedication for attenuation of haemodynamic responses to laryngoscopy and endotracheal intubation

Comparison of Intrathecal Bupivacaine with Clonidine Versus Intrathecal Bupivacaine with Fentanyl for Post-operative Pain Treatment in Lower Limb Procedures

Efficacy of Oral Gabapentin for Attenuation of Haemodynamic Responses to Laryngoscopy & Endotracheal Intubation

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