Abstract:The aim of this 3-month double-blind multicenter trial was to compare the antihypertensive efficacy and tolerability of the ACE inhibitor perindopril with those of a diuretic combination. After 1 month of receiving placebo, 165 patients with essential hypertension were randomised to perindopril 4 mg (n = 82) or to 50 mg hydrochlorothiazide + 5 mg amiloride (n = 83). The patients were treated for 3 months with monthly assessments, "uncontrolled" patients (DBP greater than 90 mm Hg) had their dosage doubled and … Show more
“…• Стабилизацию/снижение массы тела (моксо-нидин и периндоприл снижают ИМТ) [25][26][27][28][29][30] • Коррекцию метаболических нарушений (мок-сонидин и периндоприл оказывают благоприятное влияние на липидный обмен) [31][32][33].…”
Section: для чего нужная новая комбинация блокаторов раас с агонистамunclassified
“…• Стабилизацию/снижение массы тела (моксо-нидин и периндоприл снижают ИМТ) [25][26][27][28][29][30] • Коррекцию метаболических нарушений (мок-сонидин и периндоприл оказывают благоприятное влияние на липидный обмен) [31][32][33].…”
Section: для чего нужная новая комбинация блокаторов раас с агонистамunclassified
Full-dose RAAS inhibition, particularly with perindopril, effectively reduces BP, improves arterial structure and regulates cardiovascular risk factors in overweight or obese patients with hypertension.
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