A double‐blind comparison of raclopride and haloperidol in the acute phase of schizophrenia

Abstract

The British Isles Raclopride Study Group. A double-blind comparison of raclopride and haloperidol in the acute phase of schizophrenia.Acta Psychiatr Scand 1992: 86: 391-398. 0 Munksgaard 1992. This is the first comparative double-blind study of raclopride. Ninety-one patients with acute schizophrenia received either raclopride 2-8 mg twice daily or haloperidol 5-20 mg twice daily for 4 weeks. Both neuroleptics produced clinical improvements. There were no significant between-drug differences in overall efficacy measurements as assessed by the schizophrenia change sub-scale of the Comprehensive Psychopathological Rating Scale and the Krawiecka (Manchester) Rating Scale. Assessment by the Clinical Global Impression scale found haloperidol to be more effective. There were significantly fewer extrapyramidal symptoms with raclopride and a significantly lower incidence of acute dystonia. The results suggest that raclopride has an antipsychotic effect with a low incidence of extrapyramidal side effects.Raclopride((-)-( S)-3,5-dichloro-N-[ ( 1-ethyl-2-pyrrolidinyl) methyl]-2-hydroxy-6-methoxybenzamide-