A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy

Johansson, Risto; Kilkku, P.; Groenroos, M

doi:10.1016/s0305-7372(82)80032-7

Cited by 42 publications

(31 citation statements)

References 6 publications

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“…In 14 active controlled crossover trials 3% to 46% of patients preferred the standard antiemetic. 32-34 38-40 42 44 46 51-54 59 The difference in favour of cannabinoids was significant (table 2). A subgroup analysis, taking into account history of cannabis use, was not possible since this was inconsistently reported.…”

Section: Resultsmentioning

confidence: 96%

“…35 36 58-60 In nine trials, all patients were reported not to have used cannabis previously. 33 34 39 41-43 46 49 51 In the other 16 trials, it was unclear whether patients had used cannabis previously.…”

Section: Resultsmentioning

confidence: 99%

“…35 36 Chemotherapy was with high dose methotrexate35 or with doxorubicin and cytoxan 36. In one trial rates of nausea and vomiting were 100% despite prochlorperazine46; chemotherapy was with cisplatin. In two trials, the nausea rate was 85% despite alizapride53 and 83% despite prochlorperazine54; again, the chemotherapy regimen contained cisplatin.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Tramèr

Carroll²,

Campbell³

et al. 2001

BMJ

522

264

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show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Tramèr

Carroll²,

Campbell³

et al. 2001

BMJ

522

264

View full text Add to dashboard Cite

show abstract

“…Namely, the only approved medical indications correctly identifi ed by more than 50% of pharmacy students were for the treatment of cancer and glaucoma (91% and 57%, respectively). Beside this two, therapeutic uses of medical marijuana are shown in many other diseases and conditions such as spastic disorders, pain, bronchial asthma, nausea and vomiting caused by anticancer drugs, mood disorders, anorexia, epilepsy and glaucoma [18][19][20][21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Stojanović¹,

Tomas²,

Paut-Kusturica³

et al. 2017

Hosp Pharm Int Multi J

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SUMMARYIntroduction: With the growing trend for legalization of cannabis and its derivatives in Serbia, pharmacists are likely to be consulted on the safety, effi cacy, and drug-drug or drug-disease interactions of medical cannabis. Thus, the aim of our study was to assess pharmacy students' knowledge and attitude toward medical cannabis use in Serbia to determine if additional education is needed. Subjects and methods: In the study students from the fi nal year of the study program of integrated academic studies of pharmacy at the Faculty of Medicine, University of Novi Sad were asked to complete an anonymous questionnaire regarding their knowledge and attitudes on the use of cannabis and its derivatives in medical purposes. After giving their written informed consent, they were instructed by the researchers on how to complete the questionnaire. All questionnaires were administered between August 1, 2017 and August 15, 2017. The study was approved by the Ethical Committee of the Faculty of Medicine in Novi Sad; a total of 80 questionnaires were distributed. The questionnaire consisted of 3 groups of statements on which they should mark level of their agreement related to students' knowledge about the use of cannabis and its derivatives in therapeutical purposes, potential negative eff ects, dispensing in a pharmacy and legalization of cannabis and its derivatives in medical purposes. Results: Although 91.2% of the respondents agreed that cannabis and its derivatives could potentially have therapeutical eff ects, much lower percentage of respondents (51.3%) were familiar with possible therapeutical eff ects of cannabis. The same percentage of respondents learned about therapeutical eff ects of cannabis from sources other than school. About third (31.3%) of our respondents thought that the use of cannabis and its derivatives in therapeutical purposes could cause their abuse and the similar percentage of respondents (33.8%) thought that issuing cannabis and its derivatives in the pharmacy could expose a pharmacist to the certain dangers such as insisting on the issuing without the prescription or robbery. About 90% of the respondents agreed it is necessary to create clear guidelines for the use of cannabis and its derivatives in therapeutical purposes and 76.3% of the respondents thought that doctor's prescription is necessary for their dispensing in a pharmacy. Most of the respondents (75%) agreed that, based on the experiences of the countries which have

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“…Nabilone and dronabinol (THC in sesame oil) have been shown to be as effective or more effective than phenothiazines, metoclopramide and domperidone for this indication, although they have not been tested against the 5-HT 3 antagonist ondansetron [65,66]. Nabilone and dronabinol (THC in sesame oil) have been shown to be as effective or more effective than phenothiazines, metoclopramide and domperidone for this indication, although they have not been tested against the 5-HT 3 antagonist ondansetron [65,66].…”

Section: Anti-emetic Usementioning

confidence: 99%

Pharmacological actions and therapeutic uses of cannabis and cannabinoids

Kumar¹,

Chambers²,

Pertwee³

2001

Anaesthesia

164

146

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This review highlights the pharmacology, pharmacokinetics, pharmacological actions, therapeutic uses and adverse effects of cannabinoids. The effect of cannabinoids on anaesthesia is mentioned briefly. Important advances have taken place in cannabinoid research over the last few years and have led to the discovery of novel ligands. The possible clinical applications of these ligands and the direction of future research are discussed.

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A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy

Cited by 42 publications

References 6 publications

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic

Pharmacy students’ knowledge and attitudes regarding cannabis for medical purposes

Pharmacological actions and therapeutic uses of cannabis and cannabinoids

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