A double-blind controlled trial of etretinate (Tigason) and ibuprofen in psoriatic arthritis.

Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels

“…Etretinate improved the severity of psoriatic arthritis [4], while arthritic symptoms were observed during etretinate or isotretinoin treatment for acne [5,6]. In animal arthritic models, 13-cis-RA was found to inhibit rat adjuvant arthritis [7], but enhanced rat CIA without affecting anti-CII antibody level and delayed-type hypersensitivity.…”

The treatment of psoriasis and psoriatic arthritis: An interdisciplinary approach

“…11,12 Corticosteroids, either given systemically or intra-articularly, may be used to treat flares of joint symptoms, although some authors have expressed concern over potential exacerbation of skin disease. 13 Although both NSAIDs and corticosteroids may provide symptomatic relief in psoriatic arthritis, neither has been demonstrated to affect disease progression.…”

“…Etretinate was reported to be effective in both a small, controlled trial and an open-label study, although mucocutaneous adverse events proved limiting in both. 11,19 No studies have been performed with acitretin, a metabolite of etretinate that is available in the United States. In an open comparison of cyclosporine 3 to 5 mg/kg per day and methotrexate for the treatment of psoriatic arthritis, both were effective.…”

Standards of therapy of psoriatic arthritis

“…В РКИ не показано преимуществ какой-либо одной группы НПВП [50][51][52] или случаев усиления псориаза, хотя отдельные наблюдения описаны [53].…”