A double-blind, multicenter comparison between 0.05% halobetasol propionate ointment and 0.05% betamethasone dipropionate ointment in chronic plaque psoriasis

Diflorasone Diacetate Ointment 0.05% versus Betamethasone Dipropionate Ointment 0.05% in Moderate-Severe Plaque-Type Psoriasis

“…25]. Mcnsing et al [12] reported localized macroscopic adverse effects in 4% of patients treated with topical betamethasone dipropionate ointment 0.05%. An 8% incidence of localized adverse reactions was seen by the same investigators with the newest, most potent category I glucocorticoid halobetasol propionate ointment 0.05% [12].…”

“…In the United States, investigators tend to reserve the PASI for clinical trials involving systemic agents. When topical drugs [5,12,13,15. 23, 24| are tested in the United States, the PASI is seldom used.…”

“…1) and betametha sone dipropionate ointment 0.05% ( fig.2). The efficacy of both compounds in the treatment of steroid-responsive dermatoses has been established [9][10][11][12][13][14], However, they have only been directly compared once in a controlled clin ical trial [15].…”

Topical corticosteroids in plaque psoriasis: a systematic review of efficacy and treatment modalities

“…The number of enrolled patients varied from 30-1603 patients according to the trial (mean 200 patients). Forty of these studies were between-patient studies [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][22][23][24][26][27][28][29][30][31][32][34][35][36][37][38][39]41,43,44,46,[48][49][50][51]53 ; of those 11 were placebo-controlled studies 6,8,11,15,18,28,31,36,38,39,49 , and 20 studies were comparative between tw...…”

Topical Therapies for Psoriasis

“…Three clinical studies separately compared the 0.05% halobetasol propionate ointment to 0.05% clobetasol propionate ointment (Goldberg et al, 1991), 0.05% betamethasone dipropionate (BDP) ointment (Mensing et al, 1991) and 0.1% betamethasone valerate (BMV) ointment (Blum & Yawalkar 1991) in plaque psoriasis. The efficacy of the halobetasol propionate ointment was significantly superior to those of the other products in these studies.…”