A double-blind phase II randomized controlled trial of an online cognitive bias modification for interpretation program with and without psychoeducation for people with chronic pain

Sharpe, Louise; Jones, Emma; Pradhan, Poorva; Todd, Jemma; Colagiuri, Ben

doi:10.1097/j.pain.0000000000002784

Cited by 7 publications

(9 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cognitive Bias Modification for Interpretation is also low impact for recipients, with each training session taking as little as 15 minutes. 29 Although other psychological factors are likely to be relevant to pain impact in endometriosis, and should be investigated, the current results demonstrate the unique relationship between interpretation bias and pain-related impact. As such, CBM-I has potential to be included in interventions for endometriosis-related pain impact and it is clearly an empirical question as to whether CBM-I would be efficacious for people with endometriosis.…”

Section: Discussionmentioning

confidence: 60%

“…There is a voluminous literature that confirms that threat-related interpretations can be modified and when modified through a procedure known as Cognitive Bias Modification for Interpretation (CBM-I) reduce anxiety. 16,19 Preliminary evidence for CBM-I in pain shows that these interventions are effective in reducing interpretation bias and pain outcomes such as pain severity, pain interference and pain-related fear, 29 and negative emotion and attentional bias in chronic pain. 1 In the current landscape where endometriosis is predominantly medically managed, with limited efficacy and considerable cost, 4 there is a clear and urgent need for accessible and evidence-based psychological interventions, such as CBM-I.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Interpretation bias in endometriosis-related pain

Pickup,

Sharpe,

Todd

2023

Pain

Self Cite

View full text Add to dashboard Cite

Endometriosis-related pain has been predominantly medically managed, which has hindered understanding of psychological factors involved in these pain experiences. Models of chronic pain highlight the biased interpretation of ambiguous information as health threat related (interpretation bias) as an important process in the development and maintenance of chronic pain. Whether interpretation bias may also be similarly implicated in endometriosis-related pain is unclear. The current study aimed to address this gap in the literature by (1) comparing interpretation biases between a sample of participants with endometriosis and a control sample of participants without medical conditions and pain, (2) exploring relationships between interpretation bias and endometriosis-related pain outcomes, and (3) exploring whether interpretation bias moderated the relationship between endometriosis-related pain severity and pain interference. The endometriosis and healthy control samples comprised 873 and 197 participants, respectively. Participants completed online surveys assessing demographics, interpretation bias, and pain-related outcomes. Analyses revealed that interpretation bias was significantly stronger among individuals with endometriosis relative to controls, with a large effect size. Within the endometriosis sample, interpretation bias was significantly associated with increases in pain-related interference, however, interpretation bias was not associated with any other pain outcomes and did not moderate the relationship between pain severity and pain interference. This study is the first to evidence biased interpretation styles among individuals with endometriosis and to show this bias is associated with pain interference. Whether interpretation bias varies over time and whether this bias can be modified through scalable and accessible interventions to alleviate pain-related interference are avenues for future research.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Interpretation bias in endometriosis-related pain

Pickup,

Sharpe,

Todd

2023

Pain

Self Cite

View full text Add to dashboard Cite

show abstract

“…These findings are also consistent with recent research that has found that interventions to reduce interpretation bias can lead to large reductions in fear of cancer progression (Pradhan et al, submitted) and moderate reductions in pain outcomes. 32 As such, interpretation bias and fear of progression may be useful targets for future interventions to reduce the impact of pain in endometriosis.…”

Section: Discussionmentioning

confidence: 99%

“…27 This large study found that interpretation bias was associated with pain interference in people with endometriosis and also that those with endometriosis pain showed greater interpretation bias than an endometriosis-free Pearson correlations between endometriosis-specific imagery, fear of progression, and pain outcomes. 32 As such, interpretation bias and fear of progression may be useful targets for future interventions to reduce the impact of pain in endometriosis.…”

Section: Discussionmentioning

confidence: 99%

“…21,25 Interestingly, in their review Menne-Lothmann et al 25 found that interpretation bias modification interventions that used imagery instruction were related to larger cognitive and emotional effects. As interpretation bias modification has been found to lead to large improvements in fear of cancer progression (Pradhan et al, submitted) and moderate improvements in chronic pain outcomes, 32 similar interventions could be trialled in endometriosis. Fear of progression could also be directly targeted through adaptations of existing cancer fear of progression interventions such as the Conquer-Fear program.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Fear of progression, imagery, interpretation bias, and their relationship with endometriosis pain

Todd,

Pickup,

Coutts-Bain

2023

Pain

Self Cite

View full text Add to dashboard Cite

Endometriosis is a chronic gynaecological condition, of which pain is both the most common and most debilitating symptom. As with other forms of pain, there is increasing recognition of the role of psychological processes in bridging the gap between pain and pain impact, and yet these processes are not well understood in endometriosis. The aim of this study was to investigate the relevance of fear of progression, imagery, and interpretation bias in endometriosis, and their contribution to pain interference. A total of 221 participants (mean age = 38 years, SD = 7.8) with endometriosis were recruited from Endometriosis Australia. This cross-sectional study included relevant demographics and endometriosis characteristics; questionnaires to measure fear of progression, imagery, interpretation bias, and pain; and the word association task to measure interpretation bias. Participants reported high scores on the Fear of Progression Questionnaire (M = 38/60), higher than that has been found in cancer. Controlling for age and pain intensity, we found that imagery, interpretation bias, and their interaction were associated with increased fear of progression and that fear of progression was associated with greater pain-related interference. In exploratory analysis, we also found that the frequency and distress of endometriosis-related intrusive imagery were associated with greater fear of progression and pain interference, after controlling for age and pain intensity. These findings provide the first support of the importance of fear of progression in people with endometriosis and suggest possible pathways for causal investigation.

show abstract

A randomized controlled trial modifying insomnia-consistent interpretation bias in students

Duijzings,

Todd,

Notebaert

2024

Behaviour Research and Therapy

View full text Add to dashboard Cite

A double-blind phase II randomized controlled trial of an online cognitive bias modification for interpretation program with and without psychoeducation for people with chronic pain

Abstract: Supplemental Digital Content is Available in the Text.Cognitive bias modification of interpretation improved pain severity and pain interference compared with placebo. Psychoeducation did not improve the efficacy of cognitive bias modification of interpretation.

Cited by 7 publications

References 56 publications

Interpretation bias in endometriosis-related pain

Interpretation bias in endometriosis-related pain

Fear of progression, imagery, interpretation bias, and their relationship with endometriosis pain

A randomized controlled trial modifying insomnia-consistent interpretation bias in students

Contact Info

Product

Resources

About