A double-blind pilot study of transcranial ultrasound (TUS) as a five-day intervention: TUS mitigates worry among depressed participants

Reznik, Samantha J.; Sanguinetti, Joseph L.; Tyler, W.J.; Daft, C.M.W.; Allen, John J. B.

doi:10.1016/j.npbr.2020.06.004

Cited by 59 publications

(55 citation statements)

References 29 publications

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“…Computational modeling of the pressure wave in the brain can be used to improve targeting accuracy and safety (Wu et al, 2018). Although a few studies have already been conducted on human subjects (Braun et al, 2020;Legon et al, 2014;Reznik et al, 2020) work with animal models remains essential for understanding TUS mechanisms, establishing safety limits and developing safe new stimulation protocols. In addition, in animal models TUS can be readily combined with invasive recording techniques to provide new insights on neuronal computations, mechanisms and circuits.…”

Section: Discussion and Outlookmentioning

confidence: 99%

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Klink¹,

jean-francois.aubry@espci.fr²,

Ferrera³

et al. 2020

Preprint

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Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesions. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state-of-the-art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.

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Section: Discussion and Outlookmentioning

confidence: 99%

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Klink¹,

jean-francois.aubry@espci.fr²,

Ferrera³

et al. 2020

Preprint

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“…As a consequence of the delivery of repetitive LI-TUS to BF and ACC, behavioral changes resulted in disruption of decision-making behavior, possibly due to the influence of repetitive LI-TUS on modulation of targeted brain activity (Fouragnan et al, 2019;Khalighinejad et al, 2020). In human, LI-TUS has been used for treatment of mood disorders such as depression (Reznik et al, 2020;Sanguinetti et al, 2020). In summary, it is encouraging that these exciting observations have been noticed but the robustness of these effects from LI-TUS needs to be further demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…A restingstate fMRI was used to follow the functional connectivity changes between rIFC and other neural regions (e.g., subgenual cortex, orbitofrontal cortex, inferior prefrontal gyrus, dorsal anterior cingulate cortex, and entorhinal cortex) that are involved in emotional regulation (Sanguinetti et al, 2020). Similarly, Reznik et al (2020) found that stimulation of the right frontotemporal area in subjects with depression significantly improved their worry and positive mood scores compared to the control group (Reznik et al, 2020). The indirect effect of auditory confound might be influenced by the precise investigation of the effect of LI-TUS.…”

Section: Neuromodulatory Effect Of Li-tus In Humansmentioning

confidence: 99%

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

et al. 2021

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Background: Although low-intensity transcranial ultrasound stimulation (LI-TUS) has received more recognition for its neuromodulation potential, there remains a crucial knowledge gap regarding the neuromodulatory effects of LI-TUS and its potential for translation as a therapeutic tool in humans.Objective: In this review, we summarized the findings reported by recently published studies regarding the effect of LI-TUS on neuromodulation in both animals and humans. We also aim to identify challenges and opportunities for the translation process.Methods: A literature search of PubMed, Medline, EMBASE, and Web of Science was performed from January 2019 to June 2020 with the following keywords and Boolean operators: [transcranial ultrasound OR transcranial focused ultrasound OR ultrasound stimulation] AND [neuromodulation]. The methodological quality of the animal studies was assessed by the SYRCLE's risk of bias tool, and the quality of human studies was evaluated by the PEDro score and the NIH quality assessment tool.Results: After applying the inclusion and exclusion criteria, a total of 26 manuscripts (24 animal studies and two human studies) out of 508 reports were included in this systematic review. Although both inhibitory (10 studies) and excitatory (16 studies) effects of LI-TUS were observed in animal studies, only inhibitory effects have been reported in primates (five studies) and human subjects (two studies). The ultrasonic parameters used in animal and human studies are different. The SYRCLE quality score ranged from 25 to 43%, with a majority of the low scores related to performance and detection bias. The two human studies received high PEDro scores (9/10).Conclusion: LI-TUS appears to be capable of targeting both superficial and deep cerebral structures to modulate cognitive or motor behavior in both animals and humans. Further human studies are needed to more precisely define the effective modulation parameters and thereby translate this brain modulatory tool into the clinic.

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“…Therefore, by exciting these channels, increases in the alpha-band (which is inversely correlated to cortical activity) power may emerge following inhibitory litFUS modulation. Throughout the past years a few but steadily increasing number of studies used this method to safely modulate neural tissue in humans (in vivo, [33]; [54]; [53]; [55]; [77]; [71]; [52]).…”

Section: Low Intensity Transcranial Ultrasound Neuromodulationmentioning

confidence: 99%

The Right Lateral Frontal Cortex Processes Features of Emotional Faces as a Function of Their Likelihood of Occurrence

Forster¹,

Hewig²,

Allen

et al. 2021

Preprint

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The lateral frontal Cortex serves an important integrative function for converging information from a number of neural networks. It thus provides context and direction to both stimulus processing and accompanying responses. Especially in emotion related processing, the right hemisphere has often been described to serve a special role including a special sensitivity to stochastic learning and model building. In this study, the right inferior frontal gyrus (riFG) of 41 healthy participants was targeted via ultrasound neuromodulation to shed light on the involvement of this area in the representation of probabilistic context information and the processing of currently presented emotional faces. Analyses reveal that the riFG does not directly contribute to processing of currently depicted emotional stimuli but provides for information about the estimated likelihood of occurrence of stimulus features.

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A double-blind pilot study of transcranial ultrasound (TUS) as a five-day intervention: TUS mitigates worry among depressed participants

Cited by 59 publications

References 29 publications

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Combining Brain Perturbation and Neuroimaging in Non-human Primates

Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review

The Right Lateral Frontal Cortex Processes Features of Emotional Faces as a Function of Their Likelihood of Occurrence

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