A double-blind placebo-controlled study of intra-articular pentosan polysulphate (cartrophen) in patients with gonarthritis-laboratory and clinical findings

Rasaratnam, Indi; Ryan, P. F. J.; Bowman, Linda; Smith, Margaret M.; Ghosh, Peter

doi:10.1016/s1063-4584(96)80025-2

Cited by 4 publications

(3 citation statements)

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“…In contrast with other studies in dogs (Read and others 1996) and human beings (Rasaratnam and others 1996), in this study no clinical benefits from c a pps treatment were observed. It is possible that the pain and disability mechanisms at work in the postoperative cranial cruciate ligament‐deficient stifle joint may differ from those at work in chronic osteoarthritic joints like those studied by Read and others (1996).…”

Section: Methodscontrasting

confidence: 99%

Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency

Innes¹,

Barr²,

Sharif

2000

Veterinary Record

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The efficacy of calcium pentosan polysulphate (CaPPS) as a slow-acting drug for the treatment of osteoarthritis of the canine stifle joint, secondary to cranial cruciate ligament deficiency, was tested in a double-blind, placebo-controlled clinical trial over a period of one year. Dogs with the deficiency were treated surgically, matched for bodyweight, and randomly assigned to treatment or placebo groups. Active treatment began six weeks postoperatively and consisted of 10 mg/kg CaPPS orally, once weekly for four weeks, repeated every 12 weeks. The outcome was assessed in terms of function by the dogs' owners, by the radiographical grading of the osteoarthritis, and by the measurement of total sulphated glycosaminoglycans and the 5D4 epitope of keratan sulphate in the synovial fluids of affected joints. There were no differences either in functional outcome or in the radiographical progression of osteoarthritis between the two groups. Fifty-four weeks after surgery, the concentration of 5D4 in synovial fluid (expressed as change from baseline values) had decreased significantly in the treatment group compared with the placebo group (P=0.03).

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Section: Methodscontrasting

confidence: 99%

Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency

Innes¹,

Barr²,

Sharif

2000

Veterinary Record

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“…Other substances such as orgotein, radiation synovectomy (dysprosium-165hydroxide macroaggregate, yttrium-90 silicate), dextrose prolotherapy, silicone, saline lavage, saline injection without lavage, analgesic agents (bupivicaine, morphine), NSAIDs (tenoxicam, indoprofen, phenylbutazone), glucosamine, 53 somatostatin, 54 sodium pentosan polysulfate (NaPP), 55 chloroquin, 56 mucopolysaccharide polysulfuric acid ester, 57 lactic acid solution, 58 thiotepa, 59 cytostatica (thiotepa, azetepa, and osmium acid), 60 have been investigated as potentially therapeutic in the treatment of arthritic joints. Orgotein is the pharmaceutical form of the bovine enzyme Cu-Zn superoxide dismutase.…”

Section: Other Intra-articular Therapies For Knee Osteoarthritismentioning

confidence: 99%

Intra-articular therapy in osteoarthritis

Uthman

Haraoui

2003

Postgraduate Medical Journal

132

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The medical literature was reviewed from 1968–2002 using Medline and the key words “intra-articular” and “osteoarthritis” to determine the various intra-articular therapies used in the treatment of osteoarthritis. Corticosteroids and hyaluronic acid are the most frequently used intra-articular therapies in osteoarthritis. Other intra-articular substances such as orgotein, radiation synovectomy, dextrose prolotherapy, silicone, saline lavage, saline injection without lavage, analgesic agents, non-steroidal anti-inflammatory drugs, glucosamine, somatostatin, sodium pentosan polysulfate, chloroquine, mucopolysaccharide polysulfuric acid ester, lactic acid solution, and thiotepa cytostatica have been investigated as potentially therapeutic in the treatment of arthritic joints. Despite the lack of strong, convincing, and reproducible evidence that any of the intra-articular therapies significantly alters the progression of osteoarthritis, corticosteroids and hyaluronic acid are widely used in patients who have failed other therapeutic modalities for lack of efficacy or toxicity. As a practical approach for a knee with effusion, steroid injections should be considered while the presence of symptomatic “dry” knees may favour the hyaluronic acid approach. The virtual absence of serious side effects, coupled with the perceived benefits, make these approaches attractive.

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“…PPS was selected to be administered intra-articularly by the primary clinician to promote overall health of the synovial fluid at the primary joint of concern, which was shown to improve biochemical markers of osteoarthritis disease activity in a double-blind study by Rasaratnam et al in human patients with osteoarthris [ 8 ]. Additionally, when injected intra-articularly 2 to 6 times into rheumatoid arthritic joints in human patients, the molecular weight of hyaluronan increased by a median of 69% [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Transient Postoperative Hemorrhage from Elbow Arthroscopy Portals following Intra-Articular Pentosan Polysulfate Sodium Injection

Parker

Wustefeld‐Janssens

Dundas

2022

Case Reports in Veterinary Medicine

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Four adult, client owned dogs with diagnosed bilateral elbow dysplasia undergoing elbow arthroscopy for removal of fragmented medial coronoid process were identified via a retrospective database search, who also received intra-articular administration of pentosan polysulfate sodium (PPS) (Cartrophen Vet, Biopharm Australia Pty Ltd., Bondi Junction, New South Wales). Dogs had postoperative administration of 5 ml PPS injected into each elbow joint following elbow arthroscopy. Within 1-3 hours of administration, each dog experienced hemorrhage from arthroscopy incisions that was determined to be independent of surgical trauma given lack of hemorrhage intraoperatively. Pressure bandages were placed, and the hemorrhage and elevated coagulation parameters resolved 12-18 hours following intra-articular injection. No further intervention was required, and the dogs were discharged 20-26 hours postoperatively. The purpose of this case series is to describe 4 dogs who experienced transient and focal hemorrhage following off-label intra-articular administration of pentosan polysulfate sodium (PPS). While this case series is limited due to small number of cases, results following bilateral, intra-articular injection of PPS support a transient systemic coagulopathy. Though this report represents administration of PSS via a route and at doses beyond that recommended on the label, results suggest that administration of PSS in the manner described in this report should be avoided.

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A double-blind placebo-controlled study of intra-articular pentosan polysulphate (cartrophen) in patients with gonarthritis-laboratory and clinical findings

Cited by 4 publications

References 0 publications

Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency

Efficacy of oral calcium pentosan polysulphate for the treatment of osteoarthritis of the canine stifle joint secondary to cranial cruciate ligament deficiency

Intra-articular therapy in osteoarthritis

Transient Postoperative Hemorrhage from Elbow Arthroscopy Portals following Intra-Articular Pentosan Polysulfate Sodium Injection

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