A Double-blind, Placebo-controlled Study on the Effect of Buprenorphine and Fentanyl on Descending Pain Modulation

Abstract

The opioids buprenorphine and fentanyl significantly potentiate the effect of descending pain inhibition in healthy volunteers.

Hypoalgesia After Exercise and the Cold Pressor Test is Reduced in Chronic Musculoskeletal Pain Patients With High Pain Sensitivity

“…20,21 The present study extends these findings by showing a reduced CPM response in patients with high pain sensitivity compared with patients with less pain sensitivity. Although reduced CPM was found in the high pain sensitivity group with cuff algometry (PPT and pain tolerance limit), the results also showed a significant increase in the widespread PPT during the CPT and in cuff pressure pain tolerance after the CPT in both groups.…”

“…[10][11][12] Chronic musculoskeletal pain conditions in which the degree of hypoalgesia after the cold pressor test (CPT) is reduced include fibromyalgia, [13][14][15][16][17] chronic whiplash-associated disorder, 18,19 and osteoarthritis. 20,21 Similarly, chronic musculoskeletal pain conditions with attenuated hypoalgesia after exercise include fibromyalgia (FM) [22][23][24][25] and chronic whiplash-associated disorder. 26 Other studies have reported hypoalgesia in patients with musculoskeletal pain during the cold pressor test 15,27 and after exercise.…”

Reliability of Static and Dynamic Quantitative Sensory Testing in Patients With Painful Chronic Pancreatitis

“…22,23 In a previous study from our group, based on an experimental paradigm similar to that used in the present study, the reliability of CPM was good in healthy volunteers (ICC 9 0.8). 23 This is in contrast to the poor CPM reliability observed for patients with CP in the present study. The poor test-retest most likely results not only from the nature of descending pain modulation but also from factors related to the CPM paradigm.…”

“…10,23,26 Furthermore, preoperative CPM assessment has previously been shown to predict the likelihood of developing chronic postthoracotomy pain. 27 Thus, it is possible that preoperative evaluation of central pain processing in patients with CP will be useful in identifying patients who will benefit from interventional treatments (endoscopy or surgery).…”

Role of endogenous pain modulation in chronic pain mechanisms and treatment

“…In a study on opioids induced hyperalgesia, Ram et al 77 reported that CPM is reduced by opiates in patients with chronic pain. Arendt-Nielsen et al 2 reported enhancement of the CPM effect by opioids in controls. Conditioned pain modulation was not affected by lorazepam, 43 nor by oral contraceptives.…”