A Double-Blind, R CT Testing Beneficial Modulation of B DNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?

Chui, Dehua; Marcellino, Massimiliano; Marotta, Francesco; Sweed, Hala S.; Solimene, Umberto; Vignali, Andrea; Xiao, Wenhua; Ayala, Ana Patricia; Cagnuolo, U; Zerbinati, Nicola

doi:10.7860/jcdr/2014/10301.5141

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…[9,[11][12][13]. Up to date, several factors (e. g., physical activity, nutrition, sleep quality, chronic stress) are known to influence BDNF levels [2,[14][15][16][17]. In previous studies our group has shown positive effects of exercise, especially sportive dancing, on BDNF levels in elderly people [18,19].…”

Section: Introductionmentioning

confidence: 73%

Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline

Duderstadt,

Schreiber,

Burtscher

et al. 2024

Preprint

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: Background: Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neuronal plasticity. Here, we investigated the effects of controlled normobaric hypoxia (NH) combined with physical inactivity on BDNF blood levels and executive functions. Methods: Twenty-five healthy adults (25.8±3.3 years, 15 female) were analyzed in a randomized, controlled cross-over study. Each intervention began with a 30 min resting phase under normoxia (NOR), followed by a 90 min continuation of NOR or NH (peripheral oxygen saturation [SpO2] 85-80%). Serum and plasma samples were collected every 15 min. Heart rate and SpO2 were continuously measured. Before and after each exposure, cognitive tests were performed and after 24 h another follow-up blood sample was taken. Results: NH decreased SpO2 (p<.001, ηp²=.747) and increased heart rate (p=.006, ηp²=.116) significantly. The 30-min resting phase under NOR led to a significant BDNF reduction in serum (p <.001, ηp²=.581) and plasma (p <.001, ηp²=.362). Continuation of NOR further significantly reduced BDNF after another 45 min (p=.018) in serum and after 30 min (p=.040) and 90 min (p=.005) in plasma. There was no significant BDNF decline under NH. 24 h Follow-up examination showed a significant decline of serum BDNF, both after NH and NOR. Conclusion: Our results show that NH has the potential to counteract physical inactivity-induced BDNF decline. Therefore, our study emphasizes the need for a physically active lifestyle and its positive effects on BDNF. This study also demonstrates the need for a standardized protocol for future studies to determine BDNF in serum and plasma.

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Section: Introductionmentioning

confidence: 73%

Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline

Duderstadt,

Schreiber,

Burtscher

et al. 2024

Preprint

View full text Add to dashboard Cite

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The impact of dietary intervention on myokines: a narrative review

Assyov,

Chechev,

Gateva

et al. 2024

PHAR

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This review elucidates the role of dietary factors in influencing myokine secretion, complementing the recognized benefits of physical activity on metabolic health. While exercise is known to positively modulate myokines, contributing to their health-promoting effects, an exploration into how diet affects these critical cytokines remains sparse. Through analysis of the literature, this work identifies dietary patterns that markedly affect myokine levels, underscoring the complex relationship between nutrition and myokine activity. The investigation reveals that specific dietary approaches can profoundly alter myokine secretion, suggesting an essential avenue for combined dietary and exercise interventions to optimize health outcomes. These insights highlight the need for further detailed study into diet-induced myokine modulation.

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Beneficial Gut Effect of a Symbiotic-Probiotic Regimen in Healthy Stressed Individuals: Effectiveness on Permeability, Microbiota and Detoxification Parameters

Mk¹,

Marotta²,

Catanzaro³

et al. 2018

J Gastrointest Dig Syst

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A Double-Blind, R CT Testing Beneficial Modulation of B DNF in Middle-Aged, Life Style-Stressed Subjects: A Clue to Brain Protection?

Cited by 4 publications

References 37 publications

Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline

Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline

The impact of dietary intervention on myokines: a narrative review

Beneficial Gut Effect of a Symbiotic-Probiotic Regimen in Healthy Stressed Individuals: Effectiveness on Permeability, Microbiota and Detoxification Parameters

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