A double-blind randomised controlled trial of paracetamol, diclofenac or the combination for pain relief after caesarean section

Munishankar, B.; Fettes, P.D.W.; Moore, Colin; McLeod, Graeme

doi:10.1016/j.ijoa.2007.06.006

Cited by 79 publications

(58 citation statements)

References 20 publications

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“…The postoperative use of paracetamol has been shown to decrease acute pain after various surgical procedures (10). Although there is few data on the analgesic affection of a preoperative (pre-emptive) administration of paracetamol (11,12), there are no data on the efficacy of the preventive (intraoperative or the end of surgery) administration of paracetamol on the postoperative pain. The aim of this study was to evaluate the analgesic effect of administration of 1gr intravenous paracetamol at the end of surgery (preventive analgesia) on postcesarean delivery pain parameters.…”

Section: Introductionmentioning

confidence: 99%

Preventive Analgesia with Intravenous Paracetamol for Post-cesarean section Pain Control

Atashkhoyi¹,

Rasouli²,

Fardiazar³

et al. 2014

IJWHR

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Objectives: Effective pain therapy after cesarean section is essential for parturient comfort and to allow early ambulation to facilitate care of her infant. This study evaluated the analgesic effect of preventive 1gr intravenous paracetamol on postoperative pain and analgesic consumption during the 24 hours after cesarean section. Materials and Methods: One-hundred American Society of Anesthesiologists (ASA) I or II status parturient scheduled for elective cesarean section under spinal anesthesia. Patients received 1gr iv paracetamol into 100 ml normal saline (study group; n=50) or normal saline alone (placebo group; n=50) 20 minutes before the end of operation. Results: Pain scores were lower in the study group in the Post anesthesia care unit (PACU) (p<0.001) and up to 4h after operation (p<0.001). Cumulative analgesic consumption was lower in the study group (p<0.001). Conclusion: Preventive administration of 1gr iv paracetamol reduces the intensity of pain in the PACU and until 4h after operation and analgesic consumption following cesarean section.

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Section: Introductionmentioning

confidence: 99%

Preventive Analgesia with Intravenous Paracetamol for Post-cesarean section Pain Control

Atashkhoyi¹,

Rasouli²,

Fardiazar³

et al. 2014

IJWHR

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show abstract

“…He found pain intensity to be positive and higher percentage of nausea and vomiting, which could be due to morphine used in higher doses [11]. Munishankar et al also found same result as Montgomery et al [12]. Riad et al carried out a study in children undergoing inguinal hernia surgery and they used diclofenac 1 mg/kg, paracetamol 40 mg/kg and a combination of diclofenac 1 mg/kg with paracetamol 40 mg/kg, in which all drugs were given rectally 1 hour before surgery.…”

Section: Discussionmentioning

confidence: 63%

A Comparative Study of the Diclofenac with Different Preparation of Paracetamol for Post-Operative Analgesia Following Laparoscopic Cholecystectomy

Prakash¹

2016

J Anesth Clin Res

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Pain following surgery remains a very important concern which can lead to detrimental effect over cardiovascular system, central nervous system and respiratory system. To minimise pain several analgesics are used. In that matter multimodal analgesia with diclofenac and paracetamol combination is regularly used. The paracetamol available commercially is in different formulation; Paracetamol 100 mL solution for infusion (P), containing paracetamol, cysteine hydrochloride monohydrate, disodium phosphste dihydrate, hydrocholoric acid, mannitol and sodium hydroxide and Paracetamol and lignocaine 2 mL injection (PL), containing paracetamol, lignocaine hydrochloride and benzyl alcohol. We studied comparing both the formulations of these paracetamol in combination with diclofenac in laparascopic surgeries and we did not find any significant difference between these two in terms of demography, VAS, VRS and any other side effects. However the major difference in the cost between these two formulations makes a significant impact in the economic burden.

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“…3 Two different studies done on patients undergoing elective gynaecological surgeries compared paracetamol, diclofenac and their combination; gives two different results, one showing combination is better with 40% decrease in pain intensity, another showed no significant difference in pain intensity among groups. 14,15 Very few studies state that the analgesic efficacy of intravenous paracetamol was comparable and superior to that of tramadol or diclofenac which are standard postoperative analgesics used for abdominal surgery.…”

Section: Discussionmentioning

confidence: 99%

Randomized clinical trial comparing the effect of paracetamol with diclofenac in combination with on request rescue analgesic tramadol: analgesic efficacy, safety and tolerability after abdominal surgery

2016

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A double-blind randomised controlled trial of paracetamol, diclofenac or the combination for pain relief after caesarean section

Cited by 79 publications

References 20 publications

Preventive Analgesia with Intravenous Paracetamol for Post-cesarean section Pain Control

Preventive Analgesia with Intravenous Paracetamol for Post-cesarean section Pain Control

A Comparative Study of the Diclofenac with Different Preparation of Paracetamol for Post-Operative Analgesia Following Laparoscopic Cholecystectomy

Randomized clinical trial comparing the effect of paracetamol with diclofenac in combination with on request rescue analgesic tramadol: analgesic efficacy, safety and tolerability after abdominal surgery

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