A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris

Lee, Haeun; Ko, Joo Yeon; Kim, Young Hoon; Yoo, Seo Rye; Moon, Sang Ho; Kim, Nack In; Park, Chun Wook; Kim, Jeong Hwan; Koh, Hyun Ju; Park, Won Seok; Ro, Young Suck

doi:10.1684/ejd.2011.1546

Cited by 14 publications

(18 citation statements)

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“…Based on full‐text review, 12 reports failed to meet the inclusion criteria (see Fig. ), resulting in 26 studies that met the criteria for final analysis …”

Section: Resultsmentioning

confidence: 99%

Use of the hCONSORT criteria as a reporting standard for herbal interventions for common dermatoses: a systematic review

Ornelas

Routt

Kallis

et al. 2018

British Journal of Dermatology

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“…Based on full‐text review, 12 reports failed to meet the inclusion criteria (see Fig. ), resulting in 26 studies that met the criteria for final analysis …”

Section: Resultsmentioning

confidence: 99%

Use of the hCONSORT criteria as a reporting standard for herbal interventions for common dermatoses: a systematic review

Ornelas

Routt

Kallis

et al. 2018

British Journal of Dermatology

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“…The use of botanicals as adjuvant therapy is particularly promising. In one example, low‐dose topical retinoid (0.03% retinol) combined with rose extract was as effective as 0.1% adapalene (Lee et al ., ). This synergetic effect may help to reduce initial and overall retinoid dosing and therefore reduce the irritant side effects associated with topical retinoids.…”

Section: Discussionmentioning

confidence: 97%

Botanical and Phytochemical Therapy of Acne: A Systematic Review

2014

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Acne is prevalent among adolescents and adults with significant psychological effects. Standard oral and topical therapies can have significant side effects including skin irritation, gastrointestinal upset, and the development of drug-resistant bacteria. The use of botanicals and phytochemicals in dermatological products is increasingly popular, and many patients are turning to these alternative therapies for treatment of acne. This study aimed to systematically review clinical studies that have investigated the use of botanical agents in the treatment of acne. PubMed and Embase databases were searched in March 2013 for trials assessing botanical therapies in the treatment of acne vulgaris. Data from these trials are presented, and methodology of each study is assessed. Twenty-three trials met inclusion criteria. Interventions included plant extracts, herbal formulations, and phytochemicals. All studies reported favorable results, and several showed equal or superior treatment to standard therapies. No serious adverse events were reported. Few studies were methodologically rigorous. Each botanical was studied in only one or two trials. Botanicals are promising therapies for acne vulgaris although further research is warranted, especially with regard to severe acne and acne resistant to conventional therapy. There is a need for standardized methods for grading acne and assessing therapeutic effects.

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“…A combination product using retinol with hexamidine di-isothionate, known to have anti-bacterial activity, and rose extract, known to possess anti-inflammatory activity has been proposed to be an effective alternative in the treatment of mild-to-moderate acne. [33] The P. acnes biofilm model as mentioned earlier, explains the mechanism of anti-microbial resistance in acne. Coenye et al, [34] identified five herbs with potent anti-biofilm activity against P. acnes out of which, extracts from Epimedium brevicornum and Polygonum cuspidatum, as well as their active compounds (icariin and resveratrol, respectively) showed marked anti-biofilm and anti-inflammatory properties.…”

Section: Synergistic Topical Combinationsmentioning

confidence: 96%