A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson’s disease: preliminary report of benefits associated with the use of a computerized tool

Bernini, Sara; Panzarasa, Silvia; Barbieri, Marica; Sinforiani, Elena; Quaglini, Silvana; Tassorelli, Cristina; Bottiroli, Sara

doi:10.1007/s40520-020-01665-2

Cited by 26 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, the improvements were not maintained after six months. These recent studies show positive but modest results as measured by 'laboratory' neuropsychological tests, as opposed to the self-measure of executive functioning, evaluating daily functioning, used in the present study [50][51][52].…”

Section: Plos Onementioning

confidence: 43%

“…Previous cognitive training programs specifically aimed at improving executive functions in PD-MCI involved computerized or paper and pencil exercises, mostly 'drill and practice' type of training triggering bottom-up processes [9,10,49]. Two very recent studies administered traditional drill-and-practice (bottom-up) cognitive training with a particular focus on improving working memory [50], logical executive functions, episodic memory, attention and processing speed [51]. Ophey et al [50] assessed the effects of a 5-week individualized computerized training targeting working memory on 75 cognitively healthy PD patients.…”

Section: Plos Onementioning

confidence: 99%

“…Three months after the end of the training, there was only a small effect size on the test of verbal working memory [50]. Bernini et al [51] assessed the effects of a 3-week computerized cognitive training targeting logical executive functions, episodic memory, attention and processing speed. The 57 participants were 74 years old with 8 years of education, which is in the same age group but with an inferior level of education than the present sample.…”

Section: Plos Onementioning

confidence: 99%

See 2 more Smart Citations

Goal management training and psychoeducation / mindfulness for treatment of executive dysfunction in Parkinson’s disease: A feasibility pilot trial

et al. 2022

View full text Add to dashboard Cite

Introduction As there is currently no pharmacological treatment for Parkinson’s Disease Mild Cognitive Impairment (PD-MCI) with executive dysfunctions, specific cognitive interventions must be investigated. Most previous studies have tested bottom-up cognitive training programs but have not shown very good results. Objectives The aim of this study was to test ease of implementation, differential safety and preliminary efficacy of two top-down (strategy-learning) home-based, individualized, cognitive interventions: Goal Management Training (GMT), adapted for PD-MCI (Adapted-GMT), and a psychoeducation program combined with mindfulness exercises (PSYCH-Mind). Methods This was a single-blind block-randomized between-group comparative study. Twelve PD-MCI with mild executive dysfunctions were divided in four blocks and randomly assigned to any of the two interventions. The participants were included if they had PD-MCI diagnosis (no dementia), with stabilized medication. Both groups (Adapted-GMT and PSYCH-mind) received five intervention sessions each lasting 60–90 minutes for five weeks. Measures were collected at baseline, mid-point, one-week, four-week and 12-week follow-ups. Executive functions were assessed with the Dysexecutive questionnaire (DEX) and the Zoo Map Test (ZMT). Quality of life (QoL) and psychiatric symptoms were also evaluated. Repeated measures ANCOVAs (mixed linear analysis) were applied to all outcomes. Results There was one drop out, and both interventions were feasible and acceptable. Despite the small sample size limiting statistical power, patients of both groups significantly improved executive functions per the DEX-patient (Time: F(4,36) = 2.96, p = 0.033, CI95%: 10.75–15.23) and DEX-caregiver scores (Time: F(4,36) = 6.02, p = 0.017, CI95%: 9.63–17.23). Both groups significantly made fewer errors between measurement times on the ZMT (Time: F(3,36) = 16.66, p = 0.001, CI95%: 1.07–2.93). However, QoL significantly increased only in PSYCH-Mind patients at four-week follow-up (interaction Time*Group: F(4,36) = 5.31, p = 0.002, CI95%: 15.33–25.61). Conclusion Both interventions were easily implemented and proved to be safe. Because both interventions are arguably cost-effective, these pilot findings, although promising, need to be replicated in large samples. ClinicalTrials.gov Identifier NCT04636541.

show abstract

Section: Plos Onementioning

confidence: 43%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

Goal management training and psychoeducation / mindfulness for treatment of executive dysfunction in Parkinson’s disease: A feasibility pilot trial

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The data reported in the present study pertain to the secondary analysis from a Randomized Controlled Trial (RCT) , whose primary outcome was the evaluation of cognitive changes following CoRe in early stage of cognitive impairment 28 , 29 . In the context of the present study, as primary-outcome measure we considered patients’ clustering.…”

Section: Methodsmentioning

confidence: 99%

“…In the context of the present study, as CCT intervention, we used CoRe (Cognitive Rehabilitation) 26 , 27 , a software for face-to-face individual sessions developed by clinicians and bioengineers and successfully tested in patients with different types and levels of cognitive impairment due to neurodegenerative diseases 28 – 30 . Here, we showed that CoRe resulted significantly effective in improving cognitive functioning also when compared to a traditional paper-and-pencil CT, this thanks to its adaptive approach (i.e., task difficulty was adjusted depending on the subject’s performance) 31 .…”

Section: Introductionmentioning

confidence: 99%

Outcomes of a computer-based cognitive training (CoRe) in early phases of cognitive decline: a data-driven cluster analysis

Bernini¹,

Gerbasi

Panzarasa

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

The present study aimed to identify clusters of cognitive profiles as well as to explore the effects of these clusters on demographic/individual characteristics and on improvements after a computer-based cognitive training (CCT) in early cognitive impairment. Fifty-seven subjects underwent to an adaptive CCT for 3 weeks (4 individual face-to-face sessions/week of 45 min) and were evaluated at baseline (T0), post-intervention (T1), and after 6 (T2) and 12 (T3) months. Clusters of cognitive profiles were explored with k-means analysis. The analysis revealed two clusters, which were composed by 27 and 30 patients characterized by lower (Cluster 1) and higher (Cluster 2) cognitive functioning. At T1, cognitive performance improved in both groups, but Cluster 1 gained more benefits in global cognitive functioning than Cluster 2. However, at T3, Cluster 2 remained stable in its clinical condition, whereas Cluster 1 showed a pronounced worsening. In conclusion, Cluster 1 profile was associated with a more marked but also short-lasting responsiveness to CCT, whereas patients fitting with Cluster 2 characteristics seemed to obtain more CCT benefits in terms of stability or even delay of cognitive/functional decline. These findings may have relevant implications in informing the timing and modality of delivery of CCT.

show abstract

Advances in clinical basic research: Performance, treatments, and mechanisms of Parkinson disease

Yang

Liu

et al. 2021

Ibrain

View full text Add to dashboard Cite

The loss of neuronal in the substantia nigra of the elderly contributes to striatal damage and plays a critical part in the common forms of neurodegenerative diseases such as Parkinson disease (PD). The deficit of dopamine is one of the most familiar neuropathological features of PD as well as α-Synuclein aggregation. The peripheral autonomic nervous system is al so affected negatively during the course of the disease, although the subsistent of dyskinesias and else major motor characteristic deficits take significant role in the diagnostic methods during clinical practice, which is related to a number of non-motor symptoms that might increase aggregate risks. Multiple pathways and mechanisms are involved in the molecular pathogenesis: α-Synuclein, neuronal homeostasis, mitochondrial function, oxidative stress, as well as neuroinflammation. Investigations in the last few years for diagnostic biomarkers used neuroimaging, including single photon emission computed tomography as well as cutting-edge magnetic resonance imaging techniques, which has been presented to facilitate discrepant diagnosis.Pharmacological treatment is also important and efficient in equal measure. In addition to reliance on striatal dopamine replacement therapy, many solutions that are used for motor or nonmotor symptoms in these patients are available.

show abstract

A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson’s disease: preliminary report of benefits associated with the use of a computerized tool

Cited by 26 publications

References 35 publications

Goal management training and psychoeducation / mindfulness for treatment of executive dysfunction in Parkinson’s disease: A feasibility pilot trial

Goal management training and psychoeducation / mindfulness for treatment of executive dysfunction in Parkinson’s disease: A feasibility pilot trial

Outcomes of a computer-based cognitive training (CoRe) in early phases of cognitive decline: a data-driven cluster analysis

Advances in clinical basic research: Performance, treatments, and mechanisms of Parkinson disease

Contact Info

Product

Resources

About