A double-blind randomized controlled trial to assess the efficacy of daylight photodynamic therapy with methyl-aminolevulinate vs. Placebo and daylight in patients with facial photodamage

Sanclemente, Gloria; Mancilla, G.A.; Hernández, Gilma

doi:10.1016/j.ad.2015.10.002

Cited by 11 publications

(3 citation statements)

References 26 publications

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“…Lateral periorbital wrinkles treated with PDT showed better results than the control (Nd-YAG) side without serious adverse effects. Sanclemente [41] et al assessed sixty patients with symmetric facial photodamage with different treatments, MAL and daylight vs. matching placebo and daylight. They found that dPDT with MAL was safe and effective for the treatment of facial photodamage.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Wen

Hamblin

2017

Photodiagnosis and Photodynamic Therapy

164

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Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.

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Section: Clinical Applicationsmentioning

confidence: 99%

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Wen

Hamblin

2017

Photodiagnosis and Photodynamic Therapy

164

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“…These molecular effects, together with the disappearance of Tp53, a marker for epidermal carcinogenesis, may explain why PDT reverses the signs of photoageing ( 26 ). To date, clinical studies have provided little evidence that DL-PDT may also reduce facial photodamage ( 27 ). The current study investigated, for the first time, the photo-rejuvenating effects of repetitive DL-PDT with MAL.…”

Section: Discussionmentioning

confidence: 99%

Repetitive Daylight Photodynamic Therapy versus Cryosurgery for Prevention of Actinic Keratoses in Photodamaged Facial Skin: A Prospective, Randomized Controlled Multicentre Two-armed Study

Karrer

Szeimies²,

Philipp‐Dormston³

et al. 2021

Acta Derm Venereol

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Actinic keratoses are a chronic condition in ultraviolet-damaged skin, with a risk of progressing to invasive skin cancer. The aim of this study was to investigate the preventive potential of field-directed repetitive daylight photodynamic therapy for actinic keratoses. A randomized trial was performed, including 58 patients with ≥5 actinic keratoses on photodamaged facial skin, who received either 5 full-face sessions of day-light photodynamic therapy within a period of 2 years or lesion-directed cryosurgery. Primary outcome was the mean cumulative number of new actinic keratoses developed between visits 2 and 6 (visit 6 being a follow-up). This outcome was lower after daylight photodynamic therapy (7.7) compared with cryosurgery (10.2), but the difference did not reach significance (–2.5, 95% confidence interval –6.2 to 1.2; p =0.18). Several signs of photoageing (fine lines, pigmentation, roughness, erythema, sebaceous gland hyperplasia) were significantly reduced after daylight photodynamic therapy, but not after cryosurgery. Significantly less pain and fewer side-effects were reported during day-light photodynamic therapy than during cryosurgery. This study found that repetitive daylight photodynamic therapy had photo-rejuvenating effects. However, the prevention of actinic keratoses by this therapy could not be proven in a statistically reliable manner.

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“…This is likely due to a decreased release of Kit ligand and hepatocyte growth factor which are melanocyte-stimulating cytokines [49]. Furthermore, PDT reduces mottled hyperpigmentation of photoaged patient skin [50,51]. However, some authors found that in heavily pigmented lesions, an increase in the amount of melanin can be observed.…”

Section: Photodynamic Therapy In Pigmented Basal Cell Carcinomamentioning

confidence: 99%

Photodynamic Therapy in Pigmented Basal Cell Carcinoma—A Review

Mazur,

Kwiatkowska,

Reich

2023

Biomedicines

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This review summarizes the effectiveness of photodynamic therapy (PDT) in the treatment of the pigmented subtype of basal cell carcinoma (BCC) based on the current literature. PDT is a light-activated treatment, non-invasive, that selectively destroys tumor cells and tissues via the interaction of a photosensitizer, light, and molecular oxygen. It can induce cancer cell death through direct tumor vascular damage or via the induction of immune response. However, human skin is also an absorption and scattering medium since it contains hemoglobin and melanin that act as chromophores. Eumelanin can be considered a light-absorber and an intracellular antioxidant that can neutralize PDT-induced ROS and, therefore, decrease PDT success. Various factors, including tumor depth, the degree of pigmentation in malignant cells, and the individual’s skin phototype, can impact the outcome of this intricate biochemical process. It has been widely recognized that PDT exhibits limited efficacy in the treatment of pigmented lesions. However, new combination techniques such as curettage or debulking before PDT show promising results in the treatment of pigmented BCC.

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A double-blind randomized controlled trial to assess the efficacy of daylight photodynamic therapy with methyl-aminolevulinate vs. Placebo and daylight in patients with facial photodamage

Cited by 11 publications

References 26 publications

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Repetitive Daylight Photodynamic Therapy versus Cryosurgery for Prevention of Actinic Keratoses in Photodamaged Facial Skin: A Prospective, Randomized Controlled Multicentre Two-armed Study

Photodynamic Therapy in Pigmented Basal Cell Carcinoma—A Review

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