A Double-Blind Randomized Controlled Trial of Ginger for the Prevention of Postoperative Nausea and Vomiting

Arfeen, Z.; Owen, Harry; Plummer, John L.; Ilsley, A. H.; Sorby-Adams, R. A. C.; Doecke, Christopher J

doi:10.1177/0310057x9502300406

Cited by 111 publications

(65 citation statements)

References 19 publications

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“…From many clinical studies, ginger was proved to be effective in nausea and vomiting of pregnancy, because both studies of Fischer‐Rasmussen ( 14 ) and Vutyavanich ( 15 ) reported that ginger 1 g/day was more effective than placebo. However, in the control of nausea‐vomiting from other causes such as motion sickness and postoperative analgesia, ginger was claimed to be effective in some studies ( 10–13 ) , but other studies could not corroborate this finding ( 23–25 ) .…”

Section: Discussionmentioning

confidence: 99%

Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin

Manusirivithaya

Sripramote

Tangjitgamol

et al. 2004

Int J Gynecol Cancer

108

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To determine whether ginger had antiemetic effect in cisplatin-induced emesis, we conducted a randomized, double-blinded crossover study in 48 gynecologic cancer patients receiving cisplatin-based chemotherapy. Subjects were randomly allocated to regimen A or regimen B in their first cycle of the study. All patients received standard antiemetics in the first day of cisplatin administration. In regimen A, capsules of ginger root powder were given orally 1 g /day for 5 days, starting on the first day of chemotherapy. In regimen B, placebo was given on the first day and metoclopramide was given orally thereafter for 4 days. The patients were then crossed over to receive the other antiemetic regimen in their next cycle of chemotherapy. Among 43 evaluable patients who received both cycles of treatment, success in controls of nausea and emesis were not significantly different between the two regimens in both acute and delayed phases. Restlessness, as a side effect, occurred more often in metoclopramide arm compared to ginger arm (P=0.109). In conclusion, addition of ginger to standard antiemetic regimen has no advantage in reducing nausea or vomiting in acute phase of cisplatin-induced emesis. In delayed phase, ginger and metoclopramide have no statistically significant difference in efficacy.

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Section: Discussionmentioning

confidence: 99%

Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin

Manusirivithaya

Sripramote

Tangjitgamol

et al. 2004

Int J Gynecol Cancer

108

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“…Ginger is listed as a food on the FDA's “generally regarded as safe” list. Research studies have demonstrated ginger's effectiveness against nausea associated with motion sickness, pregnancy, and surgery [2, 3, 10, 23, 34]. Previous clinical trials suggest that ginger may be effective against CIN, but design inadequacies, small numbers, and lack of dose-finding studies, limit their power and generalizability [17, 19, 24, 32, 35].…”

Section: Introductionmentioning

confidence: 99%

Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients

Ryan

Heckler

Roscoe

et al. 2011

Support Care Cancer

224

235

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Purpose Despite the widespread use of antiemetics, nausea continues to be reported by over 70% of patients receiving chemotherapy. Methods In this double blind, multicenter trial, we randomly assigned 744 cancer patients to four arms: 1) placebo, 2) 0.5g ginger, 3) 1.0g ginger, or 4) 1.5g ginger. Nausea occurrence and severity were assessed at a baseline cycle and the two following cycles during which patients were taking their assigned study medication. All patients received a 5-HT3 receptor antagonist antiemetic on Day 1 of all cycles. Patients took three capsules of ginger (250mg) or placebo twice daily for six days starting three days before the first day of chemotherapy. Patients reported the severity of nausea on a 7-point rating scale (“1” = “Not at all Nauseated” and “7” = “Extremely Nauseated”) for Days 1-4 of each cycle. The primary outcomes were to determine the dose and efficacy of ginger at reducing the severity of chemotherapy-induced nausea on Day 1 of chemotherapy. Results A total of 576 patients were included in final analysis (91% female, mean age = 53). Mixed model analyses demonstrated that all doses of ginger significantly reduced acute nausea severity compared to placebo on Day 1 of chemotherapy (p=0.003). The largest reduction in nausea intensity occurred with 0.5g and 1.0g of ginger (p=0.017 and p=0.036, respectively). Anticipatory nausea was a key factor in acute chemotherapy-induced nausea (p<0.0001). Conclusions Ginger supplementation at daily dose of 0.5g-1.0g significantly aids in reduction of the severity of acute chemotherapy-induced nausea in adult cancer patients.

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“…Other studies have reported the effects of ginger on the prevention of nausea and vomiting. Flip et al found that ginger is effective for preventing postoperative nausea and vomiting (25). On the other hand, Visalyaputra et al and Eberhart et al reported that ginger had negative effects on nausea and vomiting (26, 27).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Ginger Extract on the Incidence and Severity of Nausea and Vomiting After Cesarean Section Under Spinal Anesthesia

et al. 2016

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BackgroundNausea and vomiting are one of the most common complications of cesarean sections under spinal anesthesia. Recently, the use of drugs to treat nausea and vomiting has decreased, and nonpharmaceutical and alternative traditional medicine are often preferred.ObjectivesThis study aimed to determine the effect of ginger extract on the incidence and severity of nausea and vomiting after cesarean section under spinal anesthesia.MethodsIn this double-blind randomized clinical trial, 92 pregnant women, each of whom underwent a cesarean section under spinal anesthesia, were divided in two groups: a control group and an intervention group. The intervention group received 25 drops of ginger extract in 30 cc of water, and the control group received 30 cc of water one hour before surgery. The incidence and severity of nausea and vomiting were assessed during the surgery and two and four hours after the surgery using a self-report scale. Data analysis was performed using SPSS software and statistical tests.ResultsThere was no statistically significant difference between the two groups in terms of maternal age, duration of fasting, duration of surgery, and confounding factors (P > 0.05). According to an independent t-test, there was a significant relationship between the two groups in terms of the incidence and mean severity score of nausea and vomiting during the cesarean section (P < 0.05). However, no statistically significant relationship was found between the two groups in terms of the incidence and mean severity score of nausea and vomiting two and four hours after surgery (P > 0.05).ConclusionsThe findings of this study showed that ginger extract can be used for the prevention of nausea and vomiting during cesarean section under spinal anesthesia.

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A Double-Blind Randomized Controlled Trial of Ginger for the Prevention of Postoperative Nausea and Vomiting

Cited by 111 publications

References 19 publications

Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin

Antiemetic effect of ginger in gynecologic oncology patients receiving cisplatin

Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients

The Effect of Ginger Extract on the Incidence and Severity of Nausea and Vomiting After Cesarean Section Under Spinal Anesthesia

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