A Double-Blind Study of the Effectiveness and Specificity of Injection Therapy in Ragweed Hay Fever

Lowell, Francis C.; Franklin, William

doi:10.1056/nejm196509232731302

Cited by 263 publications

(91 citation statements)

References 10 publications

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“…Three of the patients reported no symptoms in the posttreatment ragweed season. This treatment response is similar to other previous reports using high-dose therapy (17)(18)(19)(20)(21)(22)(23)(24). Correlation of P in in vitro assays.…”

Section: Methodssupporting

confidence: 91%

“…A summary of the effects of immunotherapy on the immunologic parameters measured in this study is shown in Table I. DISCUSSION Specific immunotherapy is a widely accepted approach to the treatment of pollen-induced allergic rhinitis (17)(18)(19)(20)(21)(22)(23)(24)(25); however, the immunologic events responsible for the reported symptomatic improvement are unclear. The purpose of the present study was to examine the possible mechanisms by which immunotherapy might alter immune responsiveness utilizing newly developed in vitro techniques for measuring humoral and cellular hypersensitivity responses.…”

Section: Methodsmentioning

confidence: 84%

See 1 more Smart Citation

The effect of immunotherapy on humoral and cellular responses in ragweed hayfever.

Evans¹,

Pence²,

Kaplan³

et al. 1976

J. Clin. Invest.

140

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A B S T R A C T The effect of specific immunotherapy on several in vitro responses to ragweed antigen E has been evaluated in 17 atopic patients with ragweed hayfever. The methods employed were leukocyte histamine release, measurement of specific IgE anti-ragweed antibody and specific IgG anti-ragweed antibody, lymphocyte proliferation, and the production of two lymphocyte mediators (migration inhibitory factor and mitogenic factor). The duration of treatment and symptom improvement were also recorded for comparison.Immunotherapy was associated with a decrease in leukocyte sensitivity for histamine release to ragweed antigen E in a majority of the patients. In addition, there was a significant decrease in IgE anti-ragweed antibody and a significant increase in IgG anti-ragweed antibody. Immunotherapy also resulted in a significant decrease in lymphocyte responsiveness to ragweed antigen E as measured by proliferation and the production of mediators. Symptomatic improvement was best correlated with the presence of IgG anti-ragweed antibody responses. The production of this antibody was also associated with a decrease in lymphocyte responsiveness. The results of this study indicate that specific immunotherapy in ragweed-sensitive patients induces alterations in immunologic reactivity to ragweed antigen in vitro. This response is antigen specific, includes elements of both humoral and cellular immunity, and may account

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Section: Methodssupporting

confidence: 91%

Section: Methodsmentioning

confidence: 84%

The effect of immunotherapy on humoral and cellular responses in ragweed hayfever.

Evans¹,

Pence²,

Kaplan³

et al. 1976

J. Clin. Invest.

140

View full text Add to dashboard Cite

show abstract

“…Fifty years later a double blind, placebo-controlled study was undertaken by William Franklin, which proved beyond doubt that subcutaneous immunotherapy was effective. 6 The first description of the sublingual route was from GK Scadding and J. Brostoff and the first clinical attempts with this administration were performed only a few years later. [7][8][9] In 1986 The British Committee for the Safety of Medicines reported "since 1957, 26 patients in the UK have died from anaphylaxis induced by subcutaneous immunotherapy."…”

Section: Introductionmentioning

confidence: 99%

“…• Selected patients with animal dander or house dust mite allergy in whom allergen avoidance and pharmacotherapy fail to control symptoms 6.…”

Section: Introductionmentioning

confidence: 99%

Allergen immunotherapy for allergic respiratory diseases

Cappella

Durham

2012

Human Vaccines & Immunotherapeutics

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“…In recent controlled studies, it has been shown to result in at least partial amelioration of the symptoms of hay fever in adults and children (1)(2)(3)(4). Previous studies of the immunologic parameters of pollinosis have demonstrated that immunization with pollen allergen stimulates the production of blocking antibody (5,6), reduces the serum titer of reaginic antibody (7)(8)(9), and also decreases the in vitro allergen-induced release of histamine from the patients' leukocytes (4,10,11).…”

mentioning

confidence: 99%

Immunologic and cellular changes accompanying the therapy of pollen allergy

Levy¹,

Lichtenstein²,

Goldstein³

et al. 1971

J. Clin. Invest.

142

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A B S T R A C T We had found previously that children with ragweed hay fever were somewhat less symptomatic after preseasonal immunization with large doses of ragweed pollen extract than were placebo-treated children. To study further the immunologic changes which accompany immunotherapy, these children were treated again the following year. Each patient served as his own control.Serum blocking (IgG) antibody, measured by inhibition of antigen-induced leukocyte histamine release, was increased 20-to 40-fold after therapy. The anticipated postpollen season increase of serum reaginic (IgE) antibody, measured by passive sensitization of leukocytes from nonallergic donors, was suppressed. Instead, the mean titer was decreased after treatment. Total serum IgE levels, measured by radial radioimmunodiffusion assay, were higher than normal; were correlated with reaginic antibody titers; and also did not increase in the pollen season after treatment. The concentration of both IgE and reaginic antibody was lower in the older children, irrespective of treatment.Leukocyte response to ragweed antigen E and guinea pig anti-IgE antiserum was assessed by means of in vitro histamine release techniques. After treatment, the leukocytes of 21 patients were less sensitive (11 cases), or less reactive (10 cases), to antigen E. Response to anti-IgE antibody also was diminished after treatment. In four cases, neither anti-IgE nor antigen E induced histamine release, although both IgE protein and ragweed-specific IgE antibody were present in the patients' own sera. Clinical improvement was correlated best with decreased leukocyte sensitivity and leukocyte reactivity to ragweed antigen E. It appeared that decreased cell sensitivity was related to lower serum reaginic antibody levels. Decreased cell reactivity, in the presence of both IgE protein and IgE antibody in the serum, may indicate a change in cellular response mechanisms. These studies suggest that clinical improvement following specific immunotherapy must be the result of complex changes in the immunologic and cellular components of allergic disease. INTRODUCTIONImmunotherapy has long been the major form of treatment for pollen allergy. In recent controlled studies, it has been shown to result in at least partial amelioration of the symptoms of hay fever in adults and children (1-4). Previous studies of the immunologic parameters of pollinosis have demonstrated that immunization with pollen allergen stimulates the production of blocking antibody (5, 6), reduces the serum titer of reaginic antibody (7-9), and also decreases the in vitro allergen-induced release of histamine from the patients' leukocytes (4, 10, 11).In recent studies, reaginic antibodies, which are responsible for the sensitivity of allergic individuals to specific allergens, have been identified as IgE immunoglobulins (12). Immunoglobulins of this class are present in the serum and on the histamine-containing cells of both allergic and nonallergic individuals. The mean concentration of IgE in serum from allergic ...

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A Double-Blind Study of the Effectiveness and Specificity of Injection Therapy in Ragweed Hay Fever

Cited by 263 publications

References 10 publications

The effect of immunotherapy on humoral and cellular responses in ragweed hayfever.

The effect of immunotherapy on humoral and cellular responses in ragweed hayfever.

Allergen immunotherapy for allergic respiratory diseases

Immunologic and cellular changes accompanying the therapy of pollen allergy

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