A double burden of tuberculosis and diabetes mellitus and the role of vitamin D deficiency

Wang, Qiuzhen

doi:10.18174/472258

Cited by 1 publication

(6 citation statements)

References 51 publications

(132 reference statements)

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“…We also found bilateral involvement of the lungs and this finding is supported by Patel et al 19. Previous studies showed that diabetic individuals presented mostly with cavitation in the lungs 9 19. Our study revealed that TB in patients with diabetes presented predominantly with opacifications, similar to a study done by Bacakoglu et al 21.…”

Section: Discussionsupporting

confidence: 91%

“…There is an ongoing debate concerning the atypical radiographic presentation of TB in patients with diabetes. Some scientists reported that TB affects mostly the lower lung zones9 19 20 while others state that there was no difference with the lower lung zones only being affected in older patients 21. Our study findings support that TB mostly affects the upper and mid-lung zones.…”

Section: Discussionsupporting

confidence: 84%

“…Fasting blood glucose Elevated 10 ( Open access misdiagnosis of TB for pneumonia, 9 therefore warranting high suspicion for TB by a clinician at all times.…”

Section: Discussionmentioning

confidence: 99%

“…The few studies conducted in SSA between 2013 and 2018 reported varying prevalence ranging from 3% in South Africa7 to 6.2% in Ethiopia 8. The prevalence of TB in DM in Tanzania for the year 1990 was reported as 5.4%9 which dropped to 1.3% in 2014 10. However, the latter study was limited in having focused only on patients with diabetes presenting with cough.…”

Section: Introductionmentioning

confidence: 99%

“…4 The few studies conducted in SSA between 2013 and 2018 reported varying prevalence ranging from 3% in South Africa 7 to 6.2% in Ethiopia. 8 The prevalence of TB in DM in Tanzania for the year 1990 was reported as 5.4% 9 which…”

Section: Introductionmentioning

confidence: 99%

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Burden of active pulmonary tuberculosis among patients with diabetes in Dar es Salaam, Tanzania: a cross-sectional study

2022

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ObjectivesWe aimed to determine the prevalence, associated factors and describe the chest radiographic findings for active pulmonary tuberculosis (TB) among patients with diabetes mellitus (DM) attending a diabetic clinic in Tanzania.DesignCross-sectional study.SettingA diabetic clinic at Temeke Regional Referral Hospital in Dar es salaam, Tanzania.ParticipantsPatients with diabetes.Main outcome measuresThe prevalence and factors associated with active TB in patients with DM.ResultsAmong 623 patients with DM screened, 11 (1.8%); 95% CI 0.9 to 3.1, had active TB of which 6 (54.5%) were GeneXpert positive and 5 (45.5%) were diagnosed based on clinical symptoms and suggestive chest radiographs. The risk of active TB was lower in patients aged 45–64 years compared with age below 45 years (adjusted prevalence ratio (aPR) 0.39, 95% CI (0.11 to 0.42), p=0.001) and in patients with normal chest examination findings compared with patients with crackles or bronchial breathing sounds (aPR 0.02, 95% CI (0.01 to 0.15), p<0.01). The predominant chest radiographic findings were opacification 100% mainly in the upper and mid-lung zones.ConclusionDiabetics should be screened for pulmonary TB, particularly among individuals aged 45 years and below with crackles or bronchial breathing on auscultation of the chest. High index of suspicion could help in the early detection and control of TB.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 84%

“…Fasting blood glucose Elevated 10 ( Open access misdiagnosis of TB for pneumonia, 9 therefore warranting high suspicion for TB by a clinician at all times.…”

Section: Discussionmentioning

confidence: 99%