A Double Network Composite Hydrogel with Self-Regulating Cu<sup>2+</sup>/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

Li, Yue; Wang, Yunpeng; Ding, Yuanyuan; Fan, Xi; Ye, Liansong; Pan, Qingqing; Zhang, Bowen; Li, Peng; Luo, Kui; Hu, Bing; He, Bin; Pu, Yuji

doi:10.1021/acsnano.4c04816

ACS Nano

2024

DOI: 10.1021/acsnano.4c04816

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A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

Yue Li,

Yunpeng Wang,

Yuanyuan Ding

et al.

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Cited by 17 publications

References 59 publications

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Halometallate Ionic Liquid Dynamically Regulates Zwitterionic Hydrogels by Synergistic Multiple‐Bond Networks

Jiang,

Zhao

2024

Adv Funct Materials

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Improving the compatibility between high concentration metallic ions and zwitterions to controllable construction of coordination bonds is critical and extremely challenging. Here, a facile and effective strategy to fabricate multifunctional hydrogels by randomly copolymerizing halometallate ionic liquids (ILs) and zwitterions through electron beam irradiation is reported. Introducing metal ions into ILs can balance charges and establish moderate and stable cross‐linked networks with zwitterions. The synergistic effect of coordination bonds and multiple interactions with varying strengths endows hydrogel with outstanding stretchability, compressive strength, rapid response, advanced self‐healing ability, and excellent frost resistance. The multifunctional sensor assembled from hydrogels can timely, accurately, and stably monitor human movement, write anti‐counterfeiting and remotely transmit Morse code signals. Multiple hydrogel sensors are also assembled into a flexible sensor array to track the tactile trajectory and detect spatial distribution of force. Moreover, the obtained hydrogel displays high temperature sensitivity with resistance temperature coefficient of −3.85% °C−1 at 25–40 °C, which can detect tiny temperature changes (0.1 °C). Interestingly, the processed hydrogel can effectively modulate the transmissivity through salt triggering to achieve patterning. Considering the structural designability of halometallate ILs, this work provides new insights for the development of multifunctional hydrogels.

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Halometallate Ionic Liquid Dynamically Regulates Zwitterionic Hydrogels by Synergistic Multiple‐Bond Networks

Jiang,

Zhao

2024

Adv Funct Materials

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Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide‐Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy

Jin,

Liu,

Wang

et al. 2024

Advanced Materials

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Chronic wounds impose significant physical and mental burdens on patients. Nano‐based formulations offer a promising strategy for chronic wound healing due to their non‐invasive nature and enhanced biofilms penetration, but they often lack targeting capability or fail to achieve long‐term and synergistic effects. In this work, a multifunctional microneedle (MN) patch loaded with engineered nitric oxide (NO)‐releasing nanocarriers are presented that encapsulate an antibacterial agent and are immobilized with Concanavalin A (Con A) and NO molecules for targeted and synergistic treatment of chronic wounds. With the assistance of MNs, the nanoparticles (NPs) can directly cross bacterial biofilms and be efficiently delivered to wound tissues, where they target harmful bacteria through the specific recognition between Con A and polysaccharides on bacterial surfaces, followed by the release of the encapsulated antimicrobial agent, thereby achieving effective antibacterial effect. Moreover, the NPs generate NO in a sustained manner as they dissociate in the wound tissue, which exerts potent anti‐inflammatory action and benefits tissue regeneration, further promoting chronic wounds closure. Consequently, this work provides a novel MN patch loaded with engineered NPs designed for accelerating chronic wound healing through targeted and synergistic therapy.

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Bioactive cationic polymer-based hydrogel with Engrailed-1 gene silencing and microenvironment modulation for enhanced scarless diabetic wound healing

Hu,

Li,

Yuan

et al. 2025

Chemical Engineering Journal

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A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

Cited by 17 publications

References 59 publications

Halometallate Ionic Liquid Dynamically Regulates Zwitterionic Hydrogels by Synergistic Multiple‐Bond Networks

Halometallate Ionic Liquid Dynamically Regulates Zwitterionic Hydrogels by Synergistic Multiple‐Bond Networks

Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide‐Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy

Bioactive cationic polymer-based hydrogel with Engrailed-1 gene silencing and microenvironment modulation for enhanced scarless diabetic wound healing

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Product

Resources

About

A Double Network Composite Hydrogel with Self-Regulating Cu2+/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

Cited by 17 publications

References 59 publications

Halometallate Ionic Liquid Dynamically Regulates Zwitterionic Hydrogels by Synergistic Multiple‐Bond Networks

Halometallate Ionic Liquid Dynamically Regulates Zwitterionic Hydrogels by Synergistic Multiple‐Bond Networks

Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide‐Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy

Bioactive cationic polymer-based hydrogel with Engrailed-1 gene silencing and microenvironment modulation for enhanced scarless diabetic wound healing

Contact Info

Product

Resources

About

A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing