A dramatic case of calciphylaxis 20 years after kidney transplantation

Vanbelleghem, H; Terryn, Wim; Leuven, Leen Van; Caesbroeck, Daniël Van; Demetter, Pieter; Lameire, Norbert

doi:10.1093/ndt/gfh442

Cited by 15 publications

(11 citation statements)

References 9 publications

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“…In practical application, reports noting both the resolution of calciphylaxis and new onset of calciphylaxis after transplantation exist. 68,69 Whether this is due to changes in VSMCs that are not undone through transplantation, or the influence of hypercoagulability or other pathologic processes is currently unclear, and more work is necessary to resolve these uncertainties.…”

Section: Kidney Transplantationmentioning

confidence: 99%

Calciphylaxis: Controversies in Pathogenesis, Diagnosis and Treatment

Jeong

Domínguez

2016

The American Journal of the Medical Sciences

132

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Calcific uremic arteriolopathy, otherwise known as calciphylaxis, is a rare disease characterized by skin ulceration and tissue necrosis, likely the result of vascular calcification with accompanying intimal hypertrophy and small vessel thrombosis. Although most often associated with end-stage renal disease, it has also been seen in a number of other disorders (collectively referred to as nonuremic calciphylaxis). The purpose of this review is to summarize and analyze the currently available literature regarding the pathophysiology, risk factors, clinical presentation, diagnostic features and treatment modalities for this exceptionally uncommon illness. A series of recommended treatments is proposed for optimal treatment of calciphylaxis lesions.

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Section: Kidney Transplantationmentioning

confidence: 99%

Calciphylaxis: Controversies in Pathogenesis, Diagnosis and Treatment

Jeong

Domínguez

2016

The American Journal of the Medical Sciences

132

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“…Women outnumber men by a ratio of 3 : 1 8,9 . The time from transplantation to the onset of calciphylaxis ranges from months to more than 20 years 10,11 . The range in ages is reported to be 6 months to 83 years, with a mean age of onset estimated to be 48 ± 16 years 8 …”

Section: Introductionmentioning

confidence: 99%

Calciphylaxis

Guldbakke

Khachemoune

2007

Int J Dermatology

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“…37 However, some authors suggest that diagnosis of calciphylaxis must be based on pathological findings. 3,16 Since similar findings might be encountered in metastatic calcification, the diagnosis of calciphylaxis is reached by a combination of clinical features, skin examination and the histologic features. Painful and pruritic skin lesions localized on the lower extremities are almost characteristic of calciphylaxis.…”

Section: Discussionmentioning

confidence: 95%

“…12 It occurs mainly in patients with ESRD on dialysis but can be observed predialysis and after transplantation. [13][14][15][16][17] Although calciphylaxis is almost specific for ESRD, some subjects with normal renal function have been also reported. 18,19 Calciphylaxis is characterized by small-vessel calcification and cutaneous necrosis.…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis: A Report of Six Cases and Review of Literature

et al. 2012

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Calciphylaxis is usually a fatal condition that develops in a few chronic renal failure patients, and it is characterized by calcifications in subcutaneous arteries, infarcts in skin, and the neighboring subcutis. Calciphylaxis, once considered as a rare condition, has been reported to have an annual incidence of 1% and a prevalence of 4% in dialysis patients. We describe our clinical experience in six end-stage renal disease patients on dialysis that presented with calciphylaxis and died due to sepsis, and review the pathogenesis, epidemiology, clinical and histopathologic features, and treatment of calciphylaxis. Physicians should initially consider the possibility of calciphylaxis in case of development of skin lesions in chronic renal failure patients with impaired calcium, phosphorus, and parathyroid hormone levels. The most important cause of mortality in this condition is infection. Therefore, differential diagnosis of these lesions from systemic vasculitis in their early stages and withdrawal of immunosuppressive therapy that increases the tendency to infections are essential.

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A dramatic case of calciphylaxis 20 years after kidney transplantation

Cited by 15 publications

References 9 publications

Calciphylaxis: Controversies in Pathogenesis, Diagnosis and Treatment

Calciphylaxis: Controversies in Pathogenesis, Diagnosis and Treatment

Calciphylaxis

Calciphylaxis: A Report of Six Cases and Review of Literature

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