A Drug-Related Phototoxic Reaction and Its Possible Relationship to a Radiation-Induced Skin Reaction

Abstract

Reported is a case of an acute atypical radiation-induced dermatologic reaction in a patient with a recent history of two courses of levofloxacin within 90 days prior to starting radiotherapy.

Susceptibility to radiation adverse effects in veterans with Gulf War illness and healthy civilians

“…Findings, positioned in context of other evidence, support a shift from the construct of “ionizing radiation” to the more clinically relevant construct of “oxidizing radiation.” Findings underscore the existing recognition that differences in vulnerability to radiation effects exist 18 – 20 , 150 and that heightened vulnerability is tied to certain clinical conditions (e.g., here chemical sensitivity, GWI) and may be fostered by certain exposures. This information is important for optimizing outcomes and minimizing iatrogenic complications with radiation use for diagnosis and therapy 1 , 2 , 64 , 65 , 179 – 195 and is germane in considerations for environmental and occupational radiation exposures. OS may heighten radiosensitivity—which may be favorable for treating cancer, but is unfavorable for bystander toxicity to healthy tissue.…”

“…Some agents (such as fluoroquinolone antibiotics) have been tied to radiation sensitivity in many frequency bands—for (ionizing) medical radiation 64 , 65 , photosensitivity (ultraviolent radiation) 65 – 68 , and nonionizing radiation sensitivity 69 . (Fluoroquinolone mechanisms of action prominently involve OS and mitochondrial impairment 38 ).…”

Ultraviolet recall dermatitis reaction with sorafenib

“…In radiation recall reactions, an area of the skin that has been previously exposed to irradiation develops an acute reaction after exposure to a triggering drug [1,7,11]. It was documented that reactivation reactions may be also rarely observed in patients with no previous history of radiotherapy.…”