In recent years, the space industry has witnessed a resurgence, characterized by a notable proliferation of satellites operating at progressively lower altitudes, promising extensive global coverage and terrestrial-level data transfer speeds, while remaining cost-effective solutions. In particular, Wireless Sensor Networks (WSNs) can benefit from the wide coverage of space infrastructure due to their extensive deployment, disrupted communication nature, and the potential absence of terrestrial support. This study explored the utility of Low-Earth Orbit (LEO) satellite constellations as a communication infrastructure for interconnecting “smart” devices via ground stations in Internet of Things (IoT) scenarios. To this end, we designed and implemented a series of experiments conducted within the OMNeT++ simulator, utilizing an updated iteration of the original Open Source Satellite Simulator (OS3) framework. Our research encompassed an IoT Case Study, incorporating authentic sensor data sourced from the Smart Santander testbed. Throughout our experimentation, we investigated the impact of the constellation design parameters such as the number of satellites and orbital planes, as well as the inter-satellite link configuration on the obtained Round-Trip Time (RTT) and packet loss rates.