There are a lot of non-blind image deblurring methods, especially with the total variation (TV) model-based method. However, how to choose the parameters adaptively for regularization is a major open problem. We proposed a very novel method that is based on the TV deep network to learn the best parameters adaptively for regularization. We used deep learning and prior knowledge to set up a TV-based deep network and calculate the parameters of regularization, such as biases and weights. Therefore, we used the idea of a deep network to update these parameters automatically to avoid sophisticated calculations. Our experimental results by our proposed network are significantly better than several other methods, in respect of detail retention and anti-noise performance. At the same time, we can achieve the same effect with a minimum number of training sets, thus speeding up the calculation. INDEX TERMS Non-blind image deblurring, total variation model, deep learning.