Deep learning techniques have been widely investigated as an effective method for signal measurement in recent years. However, most existing deep learning-based methods still face difficulty in deploying on embedded platforms and perform poorly in real-time applications. To address this, this paper develops two accelerators, as the core of the signal measurement system, for intelligent signal processing. Firstly, by introducing the idea of automated framework, we propose a simplest deep neural network (DNN)-based hardware structure, which automatically maps algorithms to hardware modules, supports configurable parameters, and has the advantage of low latency, with an average inference time of only 3.5 μs. Subsequently, another accelerator is designed with the efficient hardware structure of the long short-term memory (LSTM) + DNN model, demonstrating outstanding performance with a classification accuracy of 98.82%, mean absolute error (MAE) of 0.27°, and root mean square errors (RMSE) of 0.392° after model compression. Moreover, parallel optimization strategies are exploited to further reduce latency and support simultaneous frequency and direction measurement tasks. Finally, we test the actual collected signal data on the XCVU13P field programmable gate array (FPGA). The results show that the time of inference saves 28–31% for the DNN model and 71–73% for the LSTM + DNN model compared to running on graphic processing unit (GPU). In addition, the parallel strategies further decrease the delay by 23.9% and 37.5% when processing continuous data. The FPGA-based and deep learning-assisted hardware accelerators significantly improve real-time performance and provide a promising solution for signal measurement.