This paper considers the approaches and methods for reducing the influence of multicollinearity. Great attention is paid to the question of using shrinkage estimators for this purpose. Two classes of regression models are investigated, the first of which corresponds to systems with a negative feedback, while the second class presents systems without the feedback. In the first case the use of shrinkage estimators, especially the Principal Component estimator, is inappropriate but is possible in the second case with the right choice of the regularization parameter or of the number of principal components included in the regression model. This fact is substantiated by the study of the distribution of the random variable b b β β ′ ′ − , where b is the LS estimate and β is the true coefficient, since the form of this distribution is the basic characteristic of the specified classes. For this study, a regression approximation of the distribution of the event 0 b b β β ′ ′ − < based on the Edgeworth series was developed. Also, alternative approaches are examined to resolve the multicollinearity issue, including an application of the known Inequality Constrained Least Squares method and the Dual estimator method proposed by the author. It is shown that with a priori information the Euclidean distance between the estimates and the true coefficients can be significantly reduced.