A dual-functional Embolization-Visualization System for Fluorescence image-guided Tumor Resection

Jensen, Mark Martin; Barber, Zachary B.; Khurana, Nitish; Isaacson, Kyle J.; Steinhauff, Douglas; Green, Bryant; Cappello, Joseph; Pulsipher, Abigail; Ghandehari, Hamidreza; Alt, Jeremiah A.

doi:10.7150/thno.39700

Cited by 10 publications

(8 citation statements)

References 43 publications

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“…In order to determine optimal BSA–Alexa and ICG concentrations within SEM‐I, various formulations were prepared that would allow detection over time using a near‐infrared fluorescence (NIRF) imager ( Figure a). [ 23 ] ICG is a clinically used fluorescent probe for both imaging and treatment. [ 24 ] BSA was also selected due to its structural similarity with human serum albumin and its increasing role as a drug carrier in clinical settings.…”

Section: Resultsmentioning

confidence: 99%

Silk Embolic Material for Catheter‐Directed Endovascular Drug Delivery

Albadawi

Zhang

et al. 2021

Advanced Materials

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Embolization is a catheter‐based minimally invasive procedure that deliberately occludes diseased blood vessels for treatment purposes. A novel silk‐based embolic material (SEM) that is developed and optimized to provide tandem integration of both embolization and the delivery of therapeutics is reported. Natural silk is processed into fibroin proteins of varying lengths and is combined with charged nanoclay particles to allow visibility and injectability using clinical catheters as small as 600 μm in diameter at lengths >100 cm. SEMs loaded with fluorochrome labeled bovine albumin and Nivolumab, which is among the most used immunotherapy drugs worldwide, demonstrate a sustained release profile in vitro over 28 days. In a porcine renal survival model, SEMs with labeled albumin and Nivolumab successfully embolize porcine arteries without recanalization and lead to the delivery of both albumin and Nivolumab into the interstitial space of the renal cortex. Mechanistically, it is shown that tissue delivery is most optimal when the internal elastic membrane of the embolized artery is disrupted. SEM is a potential next‐generation multifunctional embolic agent that can achieve embolization and deliver a wide range of therapeutics to treat vascular diseases including tumors.

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Section: Resultsmentioning

confidence: 99%

Silk Embolic Material for Catheter‐Directed Endovascular Drug Delivery

Albadawi

Zhang

et al. 2021

Advanced Materials

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“…Injection of this ionic liquid-based agent into tissue under image guidance produced a uniform, reproducible ablation zone in rat, rabbit, and pig livers. ICG and ExiTron, surrogates for a drug (19), and Dox distributed uniformly throughout the ablation zone in animal models. In the rat N1S1 and rabbit VX2 liver tumor models, LATTE successfully ablated these highly malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous liquid ablation agent for tumor treatment and drug delivery

et al. 2021

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Percutaneous locoregional therapies (LRTs), such as thermal ablation, are performed to limit the progression of hepatocellular carcinoma (HCC) and offer a bridge for patients waiting for liver transplantation. However, physiological challenges related to tumor location, size, and existence of multiple lesions as well as safety concerns related to potential thermal injury to adjacent tissues may preclude the use of thermal ablation or lead to its failure. Here, we showed a successful injection of an ionic liquid into tissue under image guidance, ablation of tumors in response to the injected ionic liquid, and persistence (28 days) of coinjected chemotherapy with the ionic liquid in the ablation zone. In a rat HCC model, the rabbit VX2 liver tumor model, and 12 human resected tumors, injection of the ionic liquid led to consistent tumor ablation. Combining the ionic liquid with the chemotherapy agent, doxorubicin, resulted in synergistic cytotoxicity when tested with cultured HCC cells and uniform drug distribution throughout the ablation zone when percutaneously injected into liver tumors in the rabbit liver tumor model. Because this ionic liquid preparation is simple to use, is efficacious, and has a low cost, we propose that this new LRT may bridge more patients to liver transplantation.

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“…[56] Furthermore, the short halflife (≈3-5 min) of ICG could be overcome by local delivery of ICG and blood flow restriction in the tumor, with the design of adding ICG to SELPs. [57,58] In this case, as ICG fluorescence could delineate the edge of the tumor, this design could achieve tumor bleeding control and endoscopic fluorescence imageguided tumor resection (Figure 5D), while the incorporation of ICG into SELPs could improve the gel kinetics and accelerate gelation or increase its elastic modulus. Interestingly, the slow release of ICG caused by SELPs didn't greatly affect the distance of ICG diffusion after 24 h (Figure 5E).…”

Section: Trackable Abilitymentioning

confidence: 99%

Section: Hydrogel‐mediated Local Transarterial Embolization For Cancer Therapymentioning

confidence: 99%