A dual-functional polyaniline film-based flexible electrochemical sensor for the detection of pH and lactate in sweat of the human body

Zhu, Chonghui; Xue, Hua; Zhao, Hongran; Teng, Fei; Liu, Sen; Chen, Qi‐Dai; Gao, Bing‐Rong; Zhang, Tong

doi:10.1016/j.talanta.2022.123289

Cited by 47 publications

(23 citation statements)

References 30 publications

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“…The SPCE is frequently modified using metal NPs, polyaniline (PANI), graphene, and other two-dimensional materials to prepare wearable electrochemical biosensors [ 30 , 59 , 60 , 61 , 62 , 63 ]. For instance, the graphene-modified electrode used in an amperometric lactate biosensor had a distinct redox peak with a lower potential separation peak than the unmodified electrode, showing an enhanced electron transfer rate [ 64 ].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate

Shen

Liu

et al. 2022

Biosensors

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Lactate, a crucial product of the anaerobic metabolism of carbohydrates in the human body, is of enormous significance in the diagnosis and treatment of diseases and scientific exercise management. The level of lactate in the bio-fluid is a crucial health indicator because it is related to diseases, such as hypoxia, metabolic disorders, renal failure, heart failure, and respiratory failure. For critically ill patients and those who need to regularly control lactate levels, it is vital to develop a non-invasive wearable sensor to detect lactate levels in matrices other than blood. Due to its high sensitivity, high selectivity, low detection limit, simplicity of use, and ability to identify target molecules in the presence of interfering chemicals, biosensing is a potential analytical approach for lactate detection that has received increasing attention. Various types of wearable lactate biosensors are reviewed in this paper, along with their preparation, key properties, and commonly used flexible substrate materials including polydimethylsiloxane (PDMS), polyethylene terephthalate (PET), paper, and textiles. Key performance indicators, including sensitivity, linear detection range, and detection limit, are also compared. The challenges for future development are also summarized, along with some recommendations for the future development of lactate biosensors.

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Section: Electrochemical Biosensorsmentioning

confidence: 99%

Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate

Shen

Liu

et al. 2022

Biosensors

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“…Recently, flexible laser scribed graphitic carbon [ 108 ] and dual functional electrochemical sensor using macroscopic film of polyaniline-based (PANI) biosensors were reported for lactate detection [ 109 ]. The enzyme named Lactate oxidase was immobilized in the matrix of albumin/mucin hydrogel prepared over a platinum electrode surface to create an amperometric lactate biosensor [ 110 ].…”

Section: Nanomaterial-based Biosensors For Metabolites Detectionmentioning

confidence: 99%

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

et al. 2022

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Metabolites are the intermediatory products of metabolic processes catalyzed by numerous enzymes found inside the cells. Detecting clinically relevant metabolites is important to understand their physiological and biological functions along with the evolving medical diagnostics. Rapid advances in detecting the tiny metabolites such as biomarkers that signify disease hallmarks have an immense need for high-performance identifying techniques. Low concentrations are found in biological fluids because the metabolites are difficult to dissolve in an aqueous medium. Therefore, the selective and sensitive study of metabolites as biomarkers in biological fluids is problematic. The different non-electrochemical and conventional methods need a long time of analysis, long sampling, high maintenance costs, and costly instrumentation. Hence, employing electrochemical techniques in clinical examination could efficiently meet the requirements of fully automated, inexpensive, specific, and quick means of biomarker detection. The electrochemical methods are broadly utilized in several emerging and established technologies, and electrochemical biosensors are employed to detect different metabolites. This review describes the advancement in electrochemical sensors developed for clinically associated human metabolites, including glucose, lactose, uric acid, urea, cholesterol, etc., and gut metabolites such as TMAO, TMA, and indole derivatives. Different sensing techniques are evaluated for their potential to achieve relevant degrees of multiplexing, specificity, and sensitivity limits. Moreover, we have also focused on the opportunities and remaining challenges for integrating the electrochemical sensor into the point-of-care (POC) devices.

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“…Structurally, PANI can exist in several oxidation states, including oxidized (pernigraniline), partially oxidized (emeraldine and nigraniline), and reduced forms (leucoemeraldine) [ 19 ]. The scope of application of PANI-based electrodes is wide, with literature examples including detection of glucose [ 20 ], lactate/pH [ 21 ], hydrogen peroxide [ 22 ], and heavy metal [ 23 ]. Due to their applications in both SPME and electrochemical sensing, CNT- or PANI-based SPME fibers may allow for simultaneous electrochemical and SPME-coupled GC-MS, thereby extending their scope of analytical applications.…”

Section: Introductionmentioning

confidence: 99%

A Hybrid Stainless-Steel SPME Microneedle Electrode Sensor for Dual Electrochemical and GC-MS Analysis

Mugo

Robertson

Wood

2023

Sensors

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A mechanically robust in-tube stainless steel microneedle solid phase microextraction (SPME) platform for dual electrochemical and chromatographic detection has been demonstrated. The SPME microneedle was fabricated by layer-by-layer (LbL) in-tube coating, consisting of carbon nanotube (CNT)/cellulose nanocrystal (CNC) film layered with an electrically conductive polyaniline (PANI) hydrogel layer (PANI@CNT/CNC SPME microneedle (MN)). The PANI@CNT/CNC SPME MN showed effective analysis of caffeine by GC-MS with an LOD of 26 mg/L and excellent precision across the dynamic range. Additionally, the PANI@CNT/CNC SPME MN demonstrated a 67% increase in sensitivity compared to a commercial SPME fiber, while being highly robust for repeated use without loss in performance. For electrochemical detection, the PANI@CNT/CNC SPME MN showed excellent performance for the detection of 3-caffeoylquinic acid (3-CQA). The dynamic range and limits of detection (LOD) for 3-CQA analysis were 75–448 mg/L and 11 mg/L, respectively. The PANI@CNT/CNC SPME MN was demonstrated to accurately determine the caffeine content and 3-CQA in tea samples and dark roast coffee, respectively. The PANI@CNT/CNC SPME MN was used for semiquantitative antioxidant determination and composition analysis in kiwi fruit using electrochemistry and SPME-coupled GC-MS, respectively.

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A dual-functional polyaniline film-based flexible electrochemical sensor for the detection of pH and lactate in sweat of the human body

Cited by 47 publications

References 30 publications

Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate

Recent Advances in Wearable Biosensors for Non-Invasive Detection of Human Lactate

Nanomaterial-Based Electrochemical Nanodiagnostics for Human and Gut Metabolites Diagnostics: Recent Advances and Challenges

A Hybrid Stainless-Steel SPME Microneedle Electrode Sensor for Dual Electrochemical and GC-MS Analysis

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