A dual-responsive ratiometric indicator designed for <i>in vivo</i> monitoring of oxidative stress and antioxidant capacity

Yang, Majun; Zhu, Weida; Lv, Yilin; Jiang, Bin; Jiang, Chenxia; Zhou, Xiaobo; Li, Guo; Qin, Yuling; Wang, Qi; Chen, Ziwei; Wu, Li

doi:10.1039/d3sc04081j

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…In this study, heterocycle-quinolinium and 5-nitro-indole were selected as specific recognition groups for NAD(P)H and NTR, respectively, based on our previous work. 29,36 These recognition groups were linked to corresponding fluorophores through a polymethine chain to form the indicator CyQ (Fig. 1A).…”

Section: Resultsmentioning

confidence: 99%

Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

He,

Yang,

Cui

et al. 2024

Chem. Sci.

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Section: Resultsmentioning

confidence: 99%

Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

He,

Yang,

Cui

et al. 2024

Chem. Sci.

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Rational Design of NIR‐II Ratiometric Fluorescence Probes for Accurate Bioimaging and Biosensing In Vivo

Li,

Zhang,

et al. 2024

Small Methods

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Intravital fluorescence imaging in the second near‐infrared window (NIR‐II, 900–1700 nm) has emerged as a promising method for non‐invasive diagnostics in complex biological systems due to its advantages of less background interference, high tissue penetration depth, high imaging contrast, and sensitivity. However, traditional NIR‐II fluorescence imaging, which is characterized by the “always on” or “turn on” mode, lacks the ability of quantitative detection, leading to low reproducibility and reliability during bio‐detection. In contrast, NIR‐II ratiometric fluorescence imaging can realize quantitative and reliable analysis and detection in vivo by providing reference signals for fluorescence correction, generating new opportunities and prospects during in vivo bioimaging and biosensing. In this review, the current design strategies and sensing mechanisms of NIR‐II ratiometric fluorescence probes for bioimaging and biosensing applications are systematically summarized. Further, current challenges, future perspectives and opportunities for designing NIR‐II ratiometric fluorescence probes are also discussed. It is hoped that this review can provide effective guidance for the design of NIR‐II ratiometric fluorescence probes and promote its adoption in reliable biological imaging and sensing in vivo.

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Dual oxidative stress biomarkers co-recognition in periodontal microenvironment: A flexible and low-power consumption nanozyme sensing platform

Du,

Sun,

Ding

et al. 2024

Biosensors and Bioelectronics

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A dual-responsive ratiometric indicator designed for in vivo monitoring of oxidative stress and antioxidant capacity

Abstract: The imbalance between oxidative stress and antioxidant capacity is strongly associated with the development of numerous degenerative diseases, including cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Therefore, monitoring oxidative stress...

Cited by 3 publications

References 46 publications

Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

Rational Design of NIR‐II Ratiometric Fluorescence Probes for Accurate Bioimaging and Biosensing In Vivo

Dual oxidative stress biomarkers co-recognition in periodontal microenvironment: A flexible and low-power consumption nanozyme sensing platform

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