A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancer

Xu, Weiqing; Qian, Junmin; Hou, Guoqing; Wang, Yaping; Wang, Jinlei; Sun, Tao; Ji, Lijie; Suo, Aili; Yao, Yu

doi:10.1016/j.actbio.2018.11.026

Cited by 146 publications

(88 citation statements)

References 71 publications

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“…The final Nano platform bears fluorescent imaging and active targeting capacities, respectively. In this study the authors not only demonstrated that HER2 and CD44 receptors-mediated dualtargeting strategy significantly enhanced the cellular uptake of GNR-HA-ALA/Cy7.5-HER2 but also that the combined PDT/PTT treatment had significantly superior antitumor effect than PDT or PTT alone both in the MCF-7 cells model as well as in pre-clinical studies [128] . Additionally, studies performed in human breast derived cell lines have shown that supersaturated hypericin (HYP) encapsulated on Pluronic® P123 (HYP/P123) micelles presented high stability and high rates of binding to cells, which resulted in their selective internalization in MCF-7, indicating their potential to permeate the membrane of these cells.…”

Section: Perspectivesmentioning

confidence: 73%

Photodynamic therapy in cancer treatment - an update review

Santos¹,

Almeida²,

Terra³

et al. 2019

JCMT

320

327

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Cancer remains a worldwide health problem, being the disease with the highest impact on global health. Even with all the recent technological improvements, recurrence and metastasis still are the main cause of death. Since photodynamic therapy (PDT) does not compromise other treatment options and presents reduced long-term morbidity when compared with chemotherapy or radiotherapy, it appears as a promising alternative treatment for controlling malignant diseases. In this review, we set out to perform a broad up-date on PDT in cancer research and treatment, discussing how this approach has been applied and what it could add to breast cancer therapy. We covered topics going from the photochemical mechanisms involved, the different cell death mechanisms being triggered by a myriad of photosensitizers up to the more recent-on-going clinical trials.Metastatic lesions are usually multiple and resistant to conventional therapies, jeopardizing successful surgical resection, chemo and radiation treatment [4] .Light has been known to provide a therapeutic potential for several thousands of years. Over 3000 years ago, since the Ancient, Indian and Chinese civilizations it has been used for the treatment of various diseases [5] mainly in combination with reactive chemicals, for example to treat conditions like vitiligo, psoriasis and skin cancer [6] . After 1895 with the discovery of the phototherapy, which rendered Niels Ryberg Finsen the Nobel prize in Physiology/Medicine in 1903 in recognition of his work on the treatment of diseases, and in particular on the treatment of lupus vulgaris by means of concentrated light rays, many studies with the use of light and chemicals emerged [7] .Photodynamic therapy (PDT) is currently being used as an alternative treatment for the control of malignant diseases [8][9][10] . It is based in the uptake of a photosensitizer (PS) molecule which, upon being excited by light in a determined wavelength, reacts with oxygen and generates oxidant species (radicals, singlet oxygen, triplet species) in target tissues, leading to cell death [11,12] . PDT cytotoxic properties have been established to be due to the oxidation of a large range of biomolecules in cells, including nucleic acids, lipids, and proteins, leading to severe alteration in cell signaling cascades or in gene expression regulation [13,14] . Like all the newly proposed treatments, there is still place for improvements and lots of resources have been invested in this field recently. In this review, we set out to perform a broad up-date on PDT and it implication in cancer research and treatment. We have covered topics going from the photochemical mechanisms involved, the different cell death mechanisms being triggered by a myriad of photosensitizers up to the more recent reported preclinical studies and on-going clinical trials. PHOTOCHEMICAL PRINCIPLES AND COMPONENTS OF PDTAs previously stated, PDT involves the photosensitized oxidation of biomolecules which can be separated in two mechanisms. In Type I, light energy passes from exc...

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Section: Perspectivesmentioning

confidence: 73%

Photodynamic therapy in cancer treatment - an update review

Santos¹,

Almeida²,

Terra³

et al. 2019

JCMT

320

327

View full text Add to dashboard Cite

show abstract

“…Currently, little is known about the relationship between typical stemness markers and the regulation of CSC metabolism, but researchers have shown that the stem cell marker CD44 may be crucial in the regulation of glycolytic metabolism[ 142 , 143 ]. The direct interaction between CD44 and the GSH transporter--solute carrier family 7 member 11 has been reported in multiple PDT articles[ 144 , 145 ], also suggesting the ability of PDT to manipulate CSCs through redox and energy metabolism.…”

Section: Impact Of Ros From Pdt On Cscsmentioning

confidence: 96%

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

Zhang

Wang

et al. 2020

WJSC

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Photodynamic therapy (PDT) is an effective and promising cancer treatment. PDT directly generates reactive oxygen species (ROS) through photochemical reactions. This oxygen-dependent exogenous ROS has anti-cancer stem cell (CSC) effect. In addition, PDT may also increase ROS production by altering metabolism, endoplasmic reticulum stress, or potential of mitochondrial membrane. It is known that the half-life of ROS in PDT is short, with high reactivity and limited diffusion distance. Therefore, the main targeting position of PDT is often the subcellular localization of photosensitizers, which is helpful for us to explain how PDT affects CSC characteristics, including differentiation, self-renewal, apoptosis, autophagy, and immunogenicity. Broadly speaking, excess ROS will damage the redox system and cause oxidative damage to molecules such as DNA, change mitochondrial permeability, activate unfolded protein response, autophagy, and CSC resting state. Therefore, understanding the molecular mechanism by which ROS affect CSCs is beneficial to improve the efficiency of PDT and prevent tumor recurrence and metastasis. In this article, we review the effects of two types of photochemical reactions on PDT, the metabolic processes, and the biological effects of ROS in different subcellular locations on CSCs.

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“…When conjugated with 5-aminolevulinic acid (ALA), Cy7.5, and anti-HER2 antibody onto hyaluronic acid (HA) moiety, the nanoparticles showed enhanced cellular uptake and efficient cell death when compared to individual therapy. The in vivo results showed the elimination of cancer cells entirely, with minimal side effects, which suggest that the developed carrier can be efficiently utilized for the treatment of BC [ 174 ]. In another study, redox-responsive nanogels, conjugated with hyaluronic acid loaded with doxorubicin, were fabricated for the treatment of cancer.…”

Section: Nanomedicine Used In the Management Of Breast Cancermentioning

confidence: 99%

Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer

et al. 2020

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Breast cancer has become one of the biggest concerns for oncologists in the past few decades because of its unpredictable etiopathology and nonavailability of personalized translational medicine. The number of women getting affected by breast cancer has increased dramatically, owing to lifestyle and environmental changes. Besides, the development of multidrug resistance has become a challenge in the therapeutic management of breast cancer. Studies reveal that the use of monotherapy is not effective in the management of breast cancer due to high toxicity and the development of resistance. Combination therapies, such as radiation therapy with adjuvant therapy, endocrine therapy with chemotherapy, and targeted therapy with immunotherapy, are found to be effective. Thus, multimodal and combination treatments, along with nanomedicine, have emerged as a promising strategy with minimum side effects and drug resistance. In this review, we emphasize the multimodal approaches and recent advancements in breast cancer treatment modalities, giving importance to the current data on clinical trials. The novel treatment approach by targeted therapy, according to type, such as luminal, HER2 positive, and triple-negative breast cancer, are discussed. Further, passive and active targeting technologies, including nanoparticles, bioconjugate systems, stimuli-responsive, and nucleic acid delivery systems, including siRNA and aptamer, are explained. The recent research exploring the role of nanomedicine in combination therapy and the possible use of artificial intelligence in breast cancer therapy is also discussed herein. The complexity and dynamism of disease changes require the constant upgrading of knowledge, and innovation is essential for future drug development for treating breast cancer.

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A dual-targeted hyaluronic acid-gold nanorod platform with triple-stimuli responsiveness for photodynamic/photothermal therapy of breast cancer

Cited by 146 publications

References 71 publications

Photodynamic therapy in cancer treatment - an update review

Photodynamic therapy in cancer treatment - an update review

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

Combination Therapy and Nanoparticulate Systems: Smart Approaches for the Effective Treatment of Breast Cancer

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