A Dual‐Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy

Wang, Hongyu; Chang, Jiao; Shi, Mingwan; Pan, Wei; Li, Na; Tang, Bo

doi:10.1002/anie.201811273

Cited by 273 publications

(178 citation statements)

References 33 publications

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“…Photothermal therapy (PTT) based on triggering of cancer cell death through the absorbance and conversion of light to induce hyperthermia is currently an important strategy for non‐invasive cancer therapy . Furthermore, the development of efficient photothermal agents (PTs) that can achieve integration of diagnosis and treatment currently represents a challenging problem for medicinal chemists …”

Section: Resultsmentioning

confidence: 99%

Conjugated‐Polymer‐Based Nanoparticles with Efficient NIR‐II Fluorescent, Photoacoustic and Photothermal Performance

Miao

et al. 2019

ChemBioChem

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Fluorescence imaging (FI) and photoacoustic imaging (PA) play important roles in the real‐time assessment of cell‐based therapies. However, the limitations of conventional organic fluorescence contrast agents and the narrow range of the emission wavelength in the first near‐infrared (NIR‐I) window (750–900 nm) hamper applications of fluorescence imaging in living subjects. Herein, we report the design and synthesis of a short‐wave infrared FI contrast agent and PA contrast agent based on a conjugated polymer—poly{2,5‐bis[(5‐thiophen‐2‐yl)methylene]‐3,6‐bis(2‐octyldodecyl)‐2,5‐dihydropyrazine}—and its use to construct multifunctional nanoparticles to simplify photothermal therapy.

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Section: Resultsmentioning

confidence: 99%

Conjugated‐Polymer‐Based Nanoparticles with Efficient NIR‐II Fluorescent, Photoacoustic and Photothermal Performance

Miao

et al. 2019

ChemBioChem

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“…In recent years, photothermal therapy (PTT) has been demonstrated as a highly effective cancer treatment by many scientists. [7][8][9] Photothermal reagents are designed to accumulate at tumor sites, and when the tumor sites are irradiated with near-infrared (NIR) lasers, site-specific hyperthermia is induced and the cancer cells die. 10,11 The laser is an important element in PTT, and its properties in biological tissues directly affect the therapeutic effect of PTT.…”

Section: Introductionmentioning

confidence: 99%

<p>Paclitaxel/IR1061-Co-Loaded Protein Nanoparticle for Tumor-Targeted and pH/NIR-II-Triggered Synergistic Photothermal-Chemotherapy</p>

Li¹,

Qing²,

Li³

et al. 2020

IJN

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The aim of this study was to develop an "all-in-one" nanoplatform that integrates at the second near-infrared (NIR-II) region dye IR1061 and anticancer drug paclitaxel (PTX) into an apoferritin (AFN) nanocage (IR-AFN@PTX). Simultaneously, folic acid (FA), tumor target molecule, was conjugated onto IR-AFN@PTX to be IR-AFN@PTX-FA for tumortargeted and pH/NIR-II-triggered synergistic photothermal-chemotherapy. Methods: IR1061 was firstly reacted with PEG and then conjugated with AFN to be IR-AFN. Then, FA was conjugated onto the surface of IR-AFN to be IR-AFN-FA. At last, PTX was incorporated into IR-AFN-FA to fabricate a nanoplatform IR-AFN@PTX-FA. The NIR-II photothermal properties and pH/NIR-II triggered drug release were evaluated. The ability of IR-AFN@PTX-FA to target tumors was estimated using optical bioluminescence. In vitro and in vivo synergistic therapeutic effects of pH/NIR-II-triggered and tumor-targeted photothermal-chemotherapy were investigated in 4T1 tumor model. Results: IR-AFN@PTX-FA showed excellent water solubility and physiological stability, which significantly enhanced the solubility of both IR1061 and PTX. After 5 min of laser irradiation at 1064 nm, IR-AFN@PTX-FA exhibited an effective photothermal effect compared with laser irradiation at 808 nm, even when blocked with 0.6 cm thick chicken breast. Cellular uptake experiments showed IR-AFN@PTX-FA utilized clathrin-mediated and caveolae-mediated endocytosis pathways to enter 4T1 cells, and was then delivered by the endosome to the lysosome. NIR-II laser irradiation and pH could synergistically trigger PTX release, inducing significant tumor inhibition in vitro and in vivo. Conclusion: As a novel "all-in-one" nanoplatform, IR-AFN@PTX-FA was found to selectively target tumors and showed very efficient NIR-II photothermal effects and pH/NIR-II triggered drug release effects, showing a remarkable, synergistic photothermal-chemotherapy effect.

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“…With the development of medicine and the increase in the proportion of patients with tumour diseases, building a precise treatment platform will become a trend in future biomedical elds. 84,85 Especially for the treatment of malignant tumours, traditional chemotherapy and radiotherapy schemes have brought great pain to patients and have caused serious damage to the patients' bodies. In order to solve these issues, the development of imaging-induced precise therapies is of great signicance to overcome malignant tumour diseases.…”

Section: Application Of Vplnps In Biomedicinementioning

confidence: 99%

Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles

Lin

et al. 2020

Nanoscale Adv.

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A Dual‐Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy

Cited by 273 publications

References 33 publications

Conjugated‐Polymer‐Based Nanoparticles with Efficient NIR‐II Fluorescent, Photoacoustic and Photothermal Performance

Conjugated‐Polymer‐Based Nanoparticles with Efficient NIR‐II Fluorescent, Photoacoustic and Photothermal Performance

<p>Paclitaxel/IR1061-Co-Loaded Protein Nanoparticle for Tumor-Targeted and pH/NIR-II-Triggered Synergistic Photothermal-Chemotherapy</p>

Electronic structure engineering and biomedical applications of low energy-excited persistent luminescence nanoparticles

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