A dual template imprinted polymer modified electrochemical sensor based on Cu metal organic framework/mesoporous carbon for highly sensitive and selective recognition of rifampicin and isoniazid

Rawool, Chaitali R.; Srivastava, Ashwini K.

doi:10.1016/j.snb.2019.03.032

Cited by 91 publications

(42 citation statements)

References 48 publications

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“…Although these methods are generally quite sensitive and accurate, they are often costly, technically complex, time-consuming, and do not allow high throughput analysis. Recently, electrochemical methods, especially electrochemical RIF (rifampicin) sensors [10][11][12][13][14][15][16][17], have gained attention due to their outstanding merits, which includes the simplicity of the sample preparation, low cost of instrumentation, easy miniaturization, high sensitivity and selectivity. In particular, sensors based on metal oxide nanomaterials are well known for their excellent electrical, optical, thermal and catalytic properties, and large surface-to-volume ratio [18,19].…”

Section: Introductionmentioning

confidence: 99%

Multiwalled Carbon Nanotubes-CeO2 Nanorods: A “Nanonetwork” Modified Electrode for Detecting Trace Rifampicin

Zhang¹,

Helú

Zhang³

et al. 2020

Nanomaterials

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Herein, a “nanonetwork” modified electrode was fabricated based on multiwalled carbon nanotubes and CeO2 nanorods. Scanning electron microscopy, X-ray powder diffraction and zeta potential were employed to characterize this electrode. Multiwalled carbon nanotubes negatively charged and CeO2 nanorods positively charged form “nanonetwork” via electrostatic interaction. The performance of the CeO2 nanorods-based electrode remarkably improved due to the introduction of multiwalled carbon nanotubes. The detection of rifampicin (RIF) was used as a model system to probe this novel electrode. The results showed a significant electrocatalytic activity for the redox reaction of RIF. Differential pulse voltammetry was used to detect rifampicin, the reduction peak current of rifampicin linear with the logarithm of their concentrations in the range of 1.0 × 10−13–1.0 × 10−6 mol/L, The linear equation is ip = 6.72 + 0. 46lgc, the detect limit is 3.4 × 10−14 mol/L (S/N = 3). Additionally, the modified electrode exhibits enduring stability, excellent reproducibility, and high selectivity. This strategy can be successfully used to detect trace rifampicin in samples with satisfactory results.

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Section: Introductionmentioning

confidence: 99%

Multiwalled Carbon Nanotubes-CeO2 Nanorods: A “Nanonetwork” Modified Electrode for Detecting Trace Rifampicin

Zhang¹,

Helú

Zhang³

et al. 2020

Nanomaterials

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“…The presence of the Cu-MOF in the composite membrane resulted in a delay in this event, where it was observed at 337.9 °C. This is attributed to the extensive removal of the organic content of the composite membrane (MOF linkers; pyromellitic acid, and PVA/IL matrix) [ 41 ]. Moreover, the shift in this event could also be used to indicate a chemical stabilization of the polymeric matrix, through extensive H-bonding formation between the highly functionalized Cu-MOF and the PVA/IL matrix.…”

Section: Resultsmentioning

confidence: 99%

Flexible Cu3(HHTP)2 MOF Membranes for Gas Sensing Application at Room Temperature

et al. 2022

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Mixed matrix membranes (MMMs), possessing high porosity, have received extensive attention for gas sensing applications. However, those with high flexibility and significant sensitivity are rare. In this work, we report on the fabrication of a novel membrane, using Cu3(HHTP)2 MOF (Cu-MOF) embedded in a polymer matrix. A solution comprising a homogenous suspension of poly-vinyl alcohol (PVA) and ionic liquid (IL), and Cu-MOF solid particles, was cast onto a petri dish to obtain a flexible membrane (215 μm in thickness). The sensor membrane (Cu-MOF/PVA/IL), characterized for its structure and morphology, was assessed for its performance in sensing against various test gases. A detection limit of 1 ppm at 23 °C (room temperature) for H2S was achieved, with a response time of 12 s. Moreover, (Cu-MOF/PVA/IL) sensor exhibited excellent repeatability, long-term stability, and selectivity towards H2S gas. The other characteristics of the (Cu-MOF/PVA/IL) sensor include high flexibility, low cost, low-power consumption, and easy fabrication technique, which nominate this sensor as a potential candidate for use in practical industrial applications.

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“…The simultaneous determination of several analytes is of great interest in some areas, such as clinical and pharmaceutical analysis. MIPs have been applied in the simultaneous determination of different analytes as well [72][73][74]. Zheng et al developed an electrochemical MIP sensor for the direct detection of uric acid and tyrosine [72].…”

Section: Electroactive Analytesmentioning

confidence: 99%

“…In addition, a 50-fold concentration of the potential interferences dopamine, epinephrine, adenine, xanthine, ascorbic acid and glucose had a negligible effect on uric acid and tyrosine sensing by the MIP sensor, whereas with a reduced graphene oxide-modified glassy carbon electrode, pronounced interferences were found. In another work, an MIP sensor for rifampicin (RIF) and isoniazid (INZ) was developed [74]. Prior to the electropolymerization of pyrrole, the glassy carbon electrode was modified with a copper metal organic framework/mesoporous carbon composite.…”

Section: Electroactive Analytesmentioning

confidence: 99%

How Reliable Is the Electrochemical Readout of MIP Sensors?

Yarman

Scheller

2020

Sensors

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Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin MIP films. However, this process generates an overall signal, which may include nonspecific interactions with the nonimprinted surface and adsorption at the electrode surface in addition to (specific) binding to the cavities. Redox-active low-molecular-weight targets and metalloproteins enable a more specific direct quantification of their binding to MIPs by measuring the faradaic current. The in situ characterization of enzymes, MIP-based mimics of redox enzymes or enzyme-labeled targets, is based on the indication of an electroactive product. This approach allows the determination of both the activity of the bio(mimetic) catalyst and of the substrate concentration.

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A dual template imprinted polymer modified electrochemical sensor based on Cu metal organic framework/mesoporous carbon for highly sensitive and selective recognition of rifampicin and isoniazid

Cited by 91 publications

References 48 publications

Multiwalled Carbon Nanotubes-CeO2 Nanorods: A “Nanonetwork” Modified Electrode for Detecting Trace Rifampicin

Multiwalled Carbon Nanotubes-CeO2 Nanorods: A “Nanonetwork” Modified Electrode for Detecting Trace Rifampicin

Flexible Cu3(HHTP)2 MOF Membranes for Gas Sensing Application at Room Temperature

How Reliable Is the Electrochemical Readout of MIP Sensors?

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