A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock

Abstract

BackgroundTemporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy.Case presentationThis case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient. A minimally-invasive off-pump LVAD was established by draining from the left ventricle and returning to the right axillary artery with distal arterial banding to prevent right upper extremity hyperperfusion. Amniotic stem cells were injected intramyocardially at the left ventricular apex, lateral wall, inferior wall, and right subclavian vein.ConclusionThe concomitant use of the temporary minimally-invasive off-pump CentriMag placement and stem cell therapy not only provided an alternative to cardiopulmonary bypass and full-median sternotomy procedures but may have also synergistically enhanced myocardial reperfusion and regeneration.

Update on Stem Cell‐Based Therapy and Mechanical Cardiac Support: A North American Perspective

“…Other countries followed suit and in the ensuing 15 years, an additional seven case reports or case series (41)(42)(43)(44)(45)(46)(47), a single randomized multicenter trial (48) and two nonrandomized clinical trials (26,49) have been reported to date around the world.…”

“…Kazui et al were the first to attempt concurrent LVAD implantation and intramyocardial injection of allogenic amniotic stem cells, resulting in the only North American study to date that demonstrated successful ventricular recovery to allow for LVAD withdrawal after 3 weeks.…”