A dual usage smart sorbent/recognition element based on nanostructured conducting molecularly imprinted polypyrrole for simultaneous potential-induced nanoextraction/determination of ibuprofen in biomedical samples by quartz crystal microbalance sensor

Eslami, Mohammad H.; Alizadeh, Naader

doi:10.1016/j.snb.2015.06.017

Cited by 29 publications

(11 citation statements)

References 35 publications

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“…Quartz crystal microbalance (QCM) is a method, which can be easily coupled with electrochemistry when it is applied in electrochemical QCM (EQCM) setup [ 23 , 93 ]. QCM-based methods were applied for the determination: (i) of low molecular weight analytes [ 240 , 241 ], including histamine [ 242 ], naproxen [ 243 ], ibuprofen [ 244 ], S -propranolol [ 245 ]; (ii) proteins [ 246 , 247 , 248 , 249 ], ribonuclease A [ 250 ], oxidized-low-density lipoprotein in blood serum [ 251 ] and trypsin [ 252 ]; (iii) DNA and [ 249 , 253 ]. More advanced QCM-based techniques such as electrochemical QCM (EQCM) [ 23 , 93 , 254 ] and QCM with dissipation (QCM-D) [ 255 ] were also applied for the determination of analytical signals generated by molecularly imprinted and not imprinted CPs-based sensors.…”

Section: Physicochemical Methods Used For the Determination Of Anamentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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Recent challenges in biomedical diagnostics show that the development of rapid affinity sensors is very important issue. Therefore, in this review we are aiming to outline the most important directions of affinity sensors where polymer-based semiconducting materials are applied. Progress in formation and development of such materials is overviewed and discussed. Some applicability aspects of conducting polymers in the design of affinity sensors are presented. The main attention is focused on bioanalytical application of conducting polymers such as polypyrrole, polyaniline, polythiophene and poly(3,4-ethylenedioxythiophene) ortho-phenylenediamine. In addition, some other polymers and inorganic materials that are suitable for molecular imprinting technology are also overviewed. Polymerization techniques, which are the most suitable for the development of composite structures suitable for affinity sensors are presented. Analytical signal transduction methods applied in affinity sensors based on polymer-based semiconducting materials are discussed. In this review the most attention is focused on the development and application of molecularly imprinted polymer-based structures, which can replace antibodies, receptors, and many others expensive affinity reagents. The applicability of electrochromic polymers in affinity sensor design is envisaged. Sufficient biocompatibility of some conducting polymers enables to apply them as “stealth coatings” in the future implantable affinity-sensors. Some new perspectives and trends in analytical application of polymer-based semiconducting materials are highlighted.

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Section: Physicochemical Methods Used For the Determination Of Anamentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

2021

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“…The quantification of the charge cumulated (released) is carried out based on the analysis of the resonance frequency of the electrode using appropriate mathematical models that are discussed in following section of this work. − The EQCM analysis of the ink-deposited resonators is complex and requires a special preparation of the electrode such as a casting of ultrathin layers of the active material. With respect to this, the relevant published work is scarce and limited to very few capacitive systems such as a polyaniline, , polypyrrole, − and carbon and only two articles dealing with the EQCM analysis for the carbon/PPy composites. , The electrogravimetric tests of pure polypyrrole were carried out only for electrodeposited films ,− and demonstrated that both the mobility and valence of the ion play a significant role in the charge exchange process and are influenced by the pH of the electrolyte. For instance, it was possible to quantify the co-doped hydrated cations introduced simultaneously during an anion insertion.…”

Section: Introductionmentioning

confidence: 99%

Specific Surface versus Electrochemically Active Area of the Carbon/Polypyrrole Capacitor: Correlation of Ion Dynamics Studied by an Electrochemical Quartz Crystal Microbalance with BET Surface

et al. 2016

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Carbon/polypyrrole (PPy) composites are promising electrode materials for energy storage applications such as lightweight capacitors. Although these materials are composed of relatively inexpensive components, there is a gap of knowledge regarding the correlation between surface, porosity, ion exchange dynamics, and the interplay of the double layer capacitance and pseudocapacitance. In this work we evaluate the specific surface area analyzed by the BET method and the area accessible for ions using electrochemical quartz-crystal microbalance (EQCM) for SWCNT/PPy and carbon black Vulcan XC72-R/PPy composites. The study revealed that the polymer has significant influence on the pore size of the composites. Although the BET surface is low for the polypyrrole, the electrode mass change and thus the electrochemical area are large for the polymer-containing electrodes. This indicates that multiple redox active centers in the charged polymer chain are good ion scavengers. Also, for the composite electrodes, the effective charge storage occurs at the polypyrrole-carbon junctions, which are easy to design/multiply by a proper carbon-to-polymer weight ratio. The specific BET surface and electrochemically accessible surface area are both important parameters in calculation of the electrode capacitance. SWCNTs/PPy showed the highest capacitances normalized to the BET and electrochemical surface as compared to the polymer-carbon black. TEM imaging revealed very homogeneous distribution of the nanosized polymer particles onto the CNTs, which facilitates the synergistic effect of the double layer capacitance (CNTs) and pseudocapacitance (polymer). The trend in the electrode mass change in correlation with the capacitance suggest additional effects such as a solvent co-insertion into the polymer and the contribution of the charge associated with the redox activity of oxygen-containing functional groups on the carbon surface.

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“…Quartz crystal microbalance (QCM) with MIP-modified resonators [ 224 ] were used for the detection of: (i) some rather low molecular weight compounds [ 224 , 225 ], such as naproxen [ 226 ], histamine [ 227 ], S -propranolol [ 228 ], uric acid ( Figure 5 ) [ 96 ], and ibuprofen [ 229 ]; (ii) proteins [ 176 , 230 , 231 , 232 ], such as trypsin [ 233 ], ribonuclease A [ 234 ] and oxidized-low-density lipoprotein [ 235 ]; and (iii) DNA [ 232 , 236 ]. QCM-based determination of the changes of the mass of the formed MIP layer can be simultaneously performed with electrochemical methods and can be used as an electrochemical-QCM (EQCM) method [ 15 , 96 , 237 ].…”

Section: Physicochemical Methods Used In Molecularly Imprinted Polyme...mentioning

confidence: 99%

Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors

Ramanavičius

Morkvėnaitė-Vilkončienė

Samukaitė-Bubnienė

et al. 2022

Sensors

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This review is dedicated to the development of molecularly imprinted polymers (MIPs) and the application of MIPs in sensor design. MIP-based biological recognition parts can replace receptors or antibodies, which are rather expensive. Conducting polymers show unique properties that are applicable in sensor design. Therefore, MIP-based conducting polymers, including polypyrrole, polythiophene, poly(3,4-ethylenedioxythiophene), polyaniline and ortho-phenylenediamine are frequently applied in sensor design. Some other materials that can be molecularly imprinted are also overviewed in this review. Among many imprintable materials conducting polymer, polypyrrole is one of the most suitable for molecular imprinting of various targets ranging from small organics up to rather large proteins. Some attention in this review is dedicated to overview methods applied to design MIP-based sensing structures. Some attention is dedicated to the physicochemical methods applied for the transduction of analytical signals. Expected new trends and horizons in the application of MIP-based structures are also discussed.

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A dual usage smart sorbent/recognition element based on nanostructured conducting molecularly imprinted polypyrrole for simultaneous potential-induced nanoextraction/determination of ibuprofen in biomedical samples by quartz crystal microbalance sensor

Cited by 29 publications

References 35 publications

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

Advances in Molecularly Imprinted Polymers Based Affinity Sensors (Review)

Specific Surface versus Electrochemically Active Area of the Carbon/Polypyrrole Capacitor: Correlation of Ion Dynamics Studied by an Electrochemical Quartz Crystal Microbalance with BET Surface

Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors

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