A dynamic atlas of immunocyte migration from the gut

Galván-Peña, Silvia; Zhu, Yangyang; Hanna, Bola S.; Mathis, Diane; Benoist, Christophe

doi:10.1126/sciimmunol.adi0672

Cited by 14 publications

(4 citation statements)

References 84 publications

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“…More recently, the microbiota has been shown to regulate both brain and behavior, especially those associated with social functions [42], to be associated with the development of tumors [43] and with our immune system [44] to the point that microbiota transplant has become a focus in medicine.…”

Section: Messages From Medicinementioning

confidence: 99%

Diversity as a Plant Breeding Objective

Ceccarelli,

Grando

2024

Agronomy

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This review paper addresses the importance of increasing agrobiodiversity to cope with climate change and, at the same time, providing a sufficient amount of healthy food. This is in agreement with the messages from ecology and medicine indicating the advantages of biodiversity in general and agrobiodiversity in particular for the planet and for our health. Plant breeding is considered to be one of the causes of the decline in agrobiodiversity, and therefore, this paper illustrates alternatives to the commonly used approach based on centralized selection. The first alternative is decentralized participatory breeding, which adapts crops to both different agronomic environments and client preferences, representing an “option by context” model of research. The second alternative is evolutionary breeding, which is a more dynamic strategy than participatory plant breeding because it merges the advantages of decentralization with the ability of dynamic mixtures and evolutionary populations to cope with biotic and abiotic stresses and evolve, thus adapting to climate change and to the associated changes in the spectrum of pests. A crop capable of evolving as the environment around it evolves appears to be the most ideal way of responding to climate change and increasing agricultural biodiversity.

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Section: Messages From Medicinementioning

confidence: 99%

Diversity as a Plant Breeding Objective

Ceccarelli,

Grando

2024

Agronomy

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“…Irrespective of bacterial route to reach tissues, their colonization of tumors is facilitated by the permeable vasculature and immunosuppressed environment characteristic of tumors. Not rarely, bacterial transport appears to be carried out by immune cells that migrate from the gut to other parts of the body [137,138].…”

Section: Bacteria and Cancermentioning

confidence: 99%

“…This strongly suggests the translocation of gut bacteria to the breast tissue and milk [148,149]. Concerning this route, also known as the entero-mammary pathway, mounting evidence suggests that bacterial migration from the gut to breast tissue and other organs may be a common phenomenon facilitated by innate immune cells emerging from the gut [137,138,150]. Interestingly, menopause-associated immune senescence has been proposed to result in increased cytokine and chemokine production and macrophage recruitment, but reduced cytotoxicity and phagocytosis in macrophages, which seem to become impaired in bacterial clearance, potentially facilitating NTM to exit the gut [63].…”

Section: Entero-mammary Pathways and The Intratumoral Microbiomementioning

confidence: 99%

Drinking Water Microbiota, Entero-Mammary Pathways and Breast Cancer: Focus on Nontuberculous Mycobacteria

Maranha,

Alarico,

Nunes-Costa

et al. 2024

Preprint

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The prospect of drinking water serving as a conduit for gut bacteria, artificially selected by disinfection strategies and lack of monitoring at the point of use, is concerning. Certain opportunistic pathogens, notably some nontuberculous mycobacteria (NTM), often exceed coliform bacteria levels in drinking water, posing safety risks. NTM and other microbiota resist chlorination and thrive in plumbing systems. When inhaled, opportunistic NTM can infect the lungs of immunocompromised or chronically ill patients, and the elderly, primarily postmenopausal women. When ingested with drinking water, NTM often survive stomach acidity, reach the intestines, migrate to other organs using immune cells as vehicles, potentially colonizing tumor tissue, including in breast cancer. The link between the microbiome and cancer is not new, yet the recognition of intratumoral microbiomes is a recent development. Breast cancer risk rises with age, and NTM infections emerged as a concern among breast cancer patients. In addition to studies hinting at a potential association between chronic NTM infections and lung cancer, NTM have also been detected in breast tumors at levels higher than normal adjacent tissue. Evaluating the risks of continued ingestion of contaminated drinking water is paramount, especially given the ability of various bacteria to migrate from the gut to breast tissue via entero-mammary pathways. This underscores a pressing need to revise water safety monitoring guidelines and delve into hormonal factors, which includes addressing the disproportionate impact of NTM infections and breast cancer on women and examining the potential health risks posed by the cryptic and unchecked microbiota from drinking water.

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“…Beyond the transport of biomolecules through the bloodstream, mounting evidence suggests that the migration of immune cells between the skin and gut during states of immunological imbalance might be a conduit for the spread of pathological conditions and the resultant tissue damage [ 20 , 21 ]. In fact, the critical role of cell trafficking in the pathogenesis of various diseases has gained increasing recognition in recent years.…”

Section: Introductionmentioning

confidence: 99%

Immune cell trafficking: a novel perspective on the gut-skin axis

Zhang,

Yao

2024

Inflamm Regener

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Immune cell trafficking, an essential mechanism for maintaining immunological homeostasis and mounting effective responses to infections, operates under a stringent regulatory framework. Recent advances have shed light on the perturbation of cell migration patterns, highlighting how such disturbances can propagate inflammatory diseases from their origin to distal organs. This review collates and discusses current evidence that demonstrates atypical communication between the gut and skin, which are conventionally viewed as distinct immunological spheres, in the milieu of inflammation. We focus on the aberrant, reciprocal translocation of immune cells along the gut-skin axis as a pivotal factor linking intestinal and dermatological inflammatory conditions. Recognizing that the translation of these findings into clinical practices is nascent, we suggest that therapeutic strategies aimed at modulating the axis may offer substantial benefits in mitigating the widespread impact of inflammatory diseases.

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A dynamic atlas of immunocyte migration from the gut

Cited by 14 publications

References 84 publications

Diversity as a Plant Breeding Objective

Diversity as a Plant Breeding Objective

Drinking Water Microbiota, Entero-Mammary Pathways and Breast Cancer: Focus on Nontuberculous Mycobacteria

Immune cell trafficking: a novel perspective on the gut-skin axis

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