A dynamic closed-loop recirculating inhalation chamber for conducting pharmacokinetic and short-term toxicity studies

Inhalation Exposure Systems

“…Dynamic recirculating systems in which test material can be replenished have been described (Morken, 1955;Paustenbach et al. 1983;Newton et al, 1992).…”

“…Glass battery jars were mounted horizontally to form a small chamber (Spiegl et al, 1953;P a n and Jegier, 1970). Modified versions of jar-type chambers are still part of recirculating exposure systems (Anderson et al, 1979: Paustenbach et al, 1983. Desiccators require minimum modification for exposing small animals (Comstock et al, 1962;Lutz and Schlatter, 1977;Jaeger et al, 1977), and are used most often as static exposure chambers (Bolt et al, 1976;Filser and Bolt, 1981).…”